Document Detail

Mortality rates among patients with schizophrenia and tardive dyskinesia.
MedLine Citation:
PMID:  19142099     Owner:  NLM     Status:  MEDLINE    
Tardive dyskinesia (TD) is a severe and potentially irreversible movement, and previous studies have suggested increased mortality among patients with TD, but most of these studies are limited by small sample sizes and short periods of follow-up. This study examined the mortality rate of a cohort of 608 Asian patients with schizophrenia during a 6-year period and used survival analyses on time from case ascertainment to outcome (death). Data on the survival status were collected and compared between those with and without TD, and cross-tabulation was performed to show the correlation between survival and mortality rates among patients with and without TD.Seventy-two patients died, 39 (54.2%) of whom had TD previously. Of the 536 surviving cases, 239 (44.6%) have TD. The mortality rates between those with TD and those without TD were statistically significant (hazard ratio, 2.62; 95% confidence interval, 1.58-4.33; P = 0.0006).The mortality rate was dependent on age; nevertheless, the adverse effect of TD on survival rate, although reduced, remains after controlling for age (hazard ratio, 1.90; 95% confidence interval, 1.12-3.20; P = 0.017). Our finding showed a robust association with increased mortality rate and TD, but we failed to find any significant association with any specific cause of death and TD.
Siow-Ann Chong; Jenny A M Tay; Mythily Subramaniam; Elaine Pek; David Machin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  29     ISSN:  1533-712X     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-14     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Institute of Mental Health, Woodbridge Hospital, Singapore, Singapore.
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MeSH Terms
Age Factors
Aged, 80 and over
Antipsychotic Agents / adverse effects,  therapeutic use
Asian Continental Ancestry Group
Cohort Studies
Dyskinesia, Drug-Induced / epidemiology*,  mortality*
Middle Aged
Schizophrenia / drug therapy,  epidemiology*,  mortality*
Survival Rate
Reg. No./Substance:
0/Antipsychotic Agents

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