| Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first delivery. | |
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MedLine Citation:
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PMID: 20618721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The combined effects of preterm delivery, small-for-gestational-age offspring, hypertensive disorders of pregnancy, placental abruption and stillbirth on early maternal death from cardiovascular causes have not previously been described in a large cohort. We investigated the effects of pregnancy complications on early maternal death in a registry-based retrospective cohort study of 782 287 women with a first singleton delivery in Denmark 1978-2007, followed for a median of 14.8 years (range 0.25-30.2) accruing 11.6 million person-years. We employed Cox proportional hazard models of early death from cardiovascular and non-cardiovascular causes following preterm delivery, small-for-gestational-age offspring and hypertensive disorders of pregnancy. We found that preterm delivery and small-for-gestational-age were both associated with subsequent death of mothers from cardiovascular and non-cardiovascular causes. Severe pre-eclampsia was associated with death from cardiovascular causes only. There was a less than additive effect on cardiovascular mortality hazard ratios with increasing number of pregnancy complications: preterm delivery 1.90 [95% confidence intervals 1.49, 2.43]; preterm delivery and small-for-gestational-age offspring 3.30 [2.25, 4.84]; preterm delivery, small-for-gestational-age offspring and pre-eclampsia 3.85 [2.07, 7.19]. Thus, we conclude that, separately and combined, preterm delivery and small-for-gestational-age are strong markers of early maternal death from both cardiovascular and non-cardiovascular causes, while hypertensive disorders of pregnancy are markers of early death of mothers from cardiovascular causes. |
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Authors:
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Jacob A Lykke; Jens Langhoff-Roos; Charles J Lockwood; Elizabeth W Triche; Michael J Paidas |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Paediatric and perinatal epidemiology Volume: 24 ISSN: 1365-3016 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 323-30 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Roskilde Hospital, SN.P. 4000 Roskilde, Denmark. dr.lykke@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiovascular Diseases / mortality* Cohort Studies Denmark / epidemiology Female Humans Hypertension / epidemiology Infant, Newborn Infant, Small for Gestational Age Male Maternal Health Services Pre-Eclampsia / epidemiology Pregnancy Pregnancy Complications / mortality* Premature Birth / epidemiology Proportional Hazards Models Retrospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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