Document Detail

Mortality and morbidity of newly diagnosed heart failure treated with statins: a propensity-adjusted cohort study.
MedLine Citation:
PMID:  19106008     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The effect of treatment with statins on the prognosis of newly diagnosed heart failure (ndHF) is not established. We evaluate the relationship of commencing treatment with statins (CTS) with the mortality and the morbidity of ndHF, systolic (HF-DSF) and non-systolic (HF-PSF). METHODS: Prospective propensity-adjusted cohort study over 5 years on 2573 patients with ndHF. The main outcomes were all-cause and cardiovascular mortality, hospitalizations and visits. We analyze the independent relationship of CTS with the mortality and the morbidity, stratifying patients for cardiovascular co-morbidity, after adjusting for potential confounders. RESULTS: 1343 patients (52.2%) CTS, 1071 (39.5%) died, and 1729 (67.2%) were hospitalized. CTS was associated not only with a lower mortality: RR for HF-overall (CI 95%) 0.23 (0.10 to 0.36), RR for HF-PSF 0.34 (0.21 to 0.47), and RR for HF-DSF 0.20 (0.09 to 0.31), but with dose-dependency (statin>20 mg/day vs. statin<=20 mg/day): RR for HF-overall 0.49 (0.33 to 0.67), RR for HF-PSF 0.53 (0.39 to 0.70), and RR for HF-DSF 0.37 (0.26 to 0.52), and with a lower rate of hospitalization (per 100 persons-year): HF-overall (13.3 vs. 18.2), HF-PSF (13.9 vs. 19.7), and HF-DSF (12.7 vs. 16.6), (P<0.001 in all cases), even after adjustment for the propensity to take statins, or other medications, and other potential confounders. CONCLUSION: The commencement of treatment with statins is associated with a dose-dependent reduction of the mortality and of the morbidity of patients with ndHF (systolic or non-systolic).
Francisco M Gomez-Soto; Sotero P Romero; Jose A Bernal; Miguel A Escobar; Jose L Puerto; Jose L Andrey; Pedro Ruiz; Francisco Gomez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-23
Journal Detail:
Title:  International journal of cardiology     Volume:  140     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
Department of Medicine, Hospital Universitario Puerto Real, University of Cadiz, School of Medicine, Spain.
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MeSH Terms
Cohort Studies
Dose-Response Relationship, Drug
Heart Failure, Diastolic / drug therapy,  mortality
Heart Failure, Systolic / drug therapy*,  mortality*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Hypertrophy, Left Ventricular / drug therapy,  mortality
Kaplan-Meiers Estimate
Middle Aged
Multivariate Analysis
Risk Factors
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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