Document Detail


Mortality and morbidity of HIV infected patients receiving HAART: a cohort study.
MedLine Citation:
PMID:  18473789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HAART has substantially decreased mortality and morbidity among HIV-infected patients. We retrospectively analyzed morbidity and mortality in a cohort of HIV-infected adult patients with prolonged and frequent follow up (1987-2006). The study was divided in pre-HAART and HAART period for comparative reasons. In total, 615 HIV-infected patients (54 females) were included in our study. 144 died during the pre-HAART period (51.4 deaths per 100 patients). During the HAART period only 38 patients died from a total of 335 patients receiving HAART (11.3 deaths per 100 patients); the follow up in this part of the cohort was 2139 persons-years and the death incidence 1.77 deaths/per 100 person-years. The subanalysis excluding patients who died within 3 months from admission showed that death incidence among patients that have been receiving HAART from the time of diagnosis (1.2 deaths per 100 person-years) was slightly lower, compared to the death incidence of patients treated for some time with non-HAART as well (1.58 deaths per 100 persons-years). After the availability of HAART in this unit, the proportion of non-AIDS related deaths increased significantly from 8% to 40% (p<0.001); infections remained the leading cause of death in both groups of patients. Tauhe most common non-AIDS related causes of deaths were cancer and coronary disease. Our data from the studied cohort adds to the relevant literature regarding the dramatic reduction of morbidity and mortality that occurred after the availability of HAART.
Authors:
George Panos; George Samonis; Vangelis G Alexiou; Garyfallia A Kavarnou; Gerasimos Charatsis; Matthew E Falagas
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Current HIV research     Volume:  6     ISSN:  1873-4251     ISO Abbreviation:  Curr. HIV Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156990     Medline TA:  Curr HIV Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  IM    
Affiliation:
HIV Unit, 1st IKA Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiretroviral Therapy, Highly Active*
Cohort Studies
Female
Greece / epidemiology
HIV / growth & development*
HIV Infections / drug therapy*,  mortality*,  virology
Humans
Incidence
Male
Morbidity
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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