Document Detail

Mortality and major morbidity in premature infants less than 31 weeks gestational age in the decade after introduction of surfactant.
MedLine Citation:
PMID:  16521683     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Population- but also center-based mortality and major morbidity rates of premature infants are essential for prenatal counseling and quality control. METHODS: Records of all infants <30 + 6 weeks (n=674) admitted (1991-2000) to a single neonatal intensive care unit were reviewed and compared to the state-wide mortality. RESULTS: Six hundred and ninety-one infants were born in or transferred to the hospital and 600 infants (89%) survived. The mean (SD) birth weight was 1018 g (+/-314) and the mean gestational age 27+5 weeks (+/-2.0). Mortalityand morbidity did not change significantly over the 10-year period but correlated inversely with gestational age from 45% at 23(0/7) weeks to 5% at 30(6/7) weeks. Study center mortality rate for extremely low birth weight infants with birth weight <750 g was significantly lower than reported for the entire state (local 25%; Bavaria 36% p = 0.0003). Thirty-four per cent (251/600) of the survivors had one or more major complications: intracranial hemorrhage III-IV 8% (88/600), periventricular leucomalacia 6% (41/600), bronchopulmonary dysplasia with oxygen requirement at 36 weeks 20% (128/600), necrotizing enterocolitis 6% (43/600), and retinopathy of prematurity grade III-IV 9% (55/600). Survival without major morbidity increased from 32% at 23 weeks to 92% at 30 weeks. CONCLUSIONS: Despite changes in obstetric and neonatal care during the 1990s, mortality and major morbidity rates did not change significantly after the introduction of surfactant in 1991. Comparison of local, regional, national, and international mortality and morbidity rates are becoming more important in allocating resources and in decision-making at the limits of viability.
Orsolya Genzel-Boroviczény; Sabine MacWilliams; Martina Von Poblotzki; Luciano Zoppelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  85     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
Neonatology of the Pediatric University Hospital, Klinikum of the Munich University-Grosshadern, Germany.
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MeSH Terms
Bronchopulmonary Dysplasia / epidemiology,  therapy
Enterocolitis, Necrotizing / epidemiology
Germany / epidemiology
Gestational Age
Infant Mortality / trends*
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Intensive Care, Neonatal*
Intracranial Hemorrhages / epidemiology
Leukomalacia, Periventricular / epidemiology
Oxygen Inhalation Therapy
Pulmonary Surfactants / therapeutic use*
Retinopathy of Prematurity / epidemiology
Survival Analysis
Reg. No./Substance:
0/Pulmonary Surfactants

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