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Mortality indicators and risk factors for intra-abdominal hypertension in severe acute pancreatitis.
MedLine Citation:
PMID:  24833148     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract This study assessed the risk factors associated with mortality and the development of intra-abdominal hypertension (IAH) in patients with severe acute pancreatitis (SAP). To identify significant risk factors, we assessed the following variables in 102 patients with SAP: age, gender, etiology, serum amylase level, white blood cell (WBC) count, serum calcium level, Acute Physiology and Chronic Health Evaluation II (APACHE-II) score, computed tomography severity index (CTSI) score, pancreatic necrosis, surgical interventions, and multiple organ dysfunction syndrome (MODS). Statistically significant differences were identified using the Student t test and the χ (2) test. Independent risk factors for survival were analyzed by Cox proportional hazards regression. The following variables were significantly related to both mortality and IAH: WBC count, serum calcium level, serum amylase level, APACHE-II score, CTSI score, pancreatic necrosis, pancreatic necrosis >50%, and MODS. However, it was found that surgical intervention had no significant association with mortality. MODS and pancreatic necrosis >50% were found to be independent risk factors for survival in patients with SAP. Mortality and IAH from SAP were significantly related to WBC count, serum calcium level, serum amylase level, APACHE-II score, CTSI score, pancreatic necrosis, and MODS. However, Surgical intervention did not result in higher mortality. Moreover, MODS and pancreatic necrosis >50% predicted a worse prognosis in SAP patients.
Authors:
Jg Zhao; Q Liao; Yp Zhao; Y Hu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International surgery     Volume:  99     ISSN:  0020-8868     ISO Abbreviation:  Int Surg     Publication Date:    2014 May-Jun
Date Detail:
Created Date:  2014-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043524     Medline TA:  Int Surg     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  252-7     Citation Subset:  IM    
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