| Mortality indicators among chronic Chagas patients living in an endemic area. | |
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MedLine Citation:
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PMID: 19336269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chagas disease is a serious social-medical problem in Latin American countries because of its high incidence, morbidity and mortality. Our aim was to identify, from demographic, personal history, clinical and electrocardiographic variables, those that might have independent prognostic value regarding mortality, among a population of chronic Chagas patients from a single endemic area where vector transmission has been halted. METHODS AND RESULTS: Over a mean of 18.5 years, we followed up a prospective cohort of 120 individuals with chronic Chagas disease. Twenty dichotomous variables with prognostic potential for chronic Chagas disease patients were initially evaluated using the Cox model (univariable analysis), to calculate the proportional mortality risk from all causes, cardiovascular causes and sudden death, relative to each variable separately. Of these, 12 variables presenting statistical significance (p<0.05) were included in a multivariable model to determine which of them would have independent prognostic value regarding mortality. Over the follow-up, there were 42 deaths. Eight variables were proven to be independent prognostic factors for mortality, in relation to the three types of death analysed: age ≥39 years, black skin colour, high-degree right-branch block, anterosuperior division block of the left branch, high-degree right-branch block associated with anterosuperior division block of the left branch, high-degree left-branch block, polymorphic ventricular extrasystoles and PR interval ≥0.16 s. CONCLUSIONS: The presence on conventional electrocardiograms of polymorphic ventricular extrasystoles or high-degree left-branch block, among a population of chronic Chagas patients, constitutes the most important independent factor for poor prognosis. |
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Authors:
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José Geraldo Ferreira Gonçalves; Valdo José Dias Silva; Maria Cândida Calzada Borges; Aluízio Prata; Dalmo Correia |
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Publication Detail:
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Type: Journal Article Date: 2009-03-31 |
Journal Detail:
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Title: International journal of cardiology Volume: 143 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 235-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Cardiology Division, Department of Internal Medicine, Federal University of the Triângulo Mineiro, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arrhythmias, Cardiac / diagnosis, mortality* Brazil / epidemiology Chagas Cardiomyopathy / mortality*, ultrasonography Chronic Disease Electrocardiography Endemic Diseases / statistics & numerical data* Female Humans Kaplan-Meier Estimate Male Middle Aged Predictive Value of Tests Prognosis Proportional Hazards Models Risk Factors |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2010 Nov 5;145(1):64-5; author reply 66-7
[PMID:
19428129
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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