Document Detail

Mortality in systemic lupus erythematosus: active disease is the most important factor.
MedLine Citation:
PMID:  1580864     Owner:  NLM     Status:  MEDLINE    
Although systemic lupus erythematosus (SLE) no longer has the very poor prognosis that it had 50 years ago, there remains a significant mortality. We were able to determine the causes of death in 27 of the 29 patients with SLE who died over the period 1985 to 1989. This represents one and five year mortality of six and 24% respectively. In common with other studies, sepsis was a major factor, being implicated in the deaths of 37% of our patients. However, sepsis (i) occurred almost exclusively in patients with active SLE; (ii) often occurred after prolonged hospitalisation; and (iii) was a terminal event in otherwise fatal SLE in several patients. Overall, active disease was determined to be a cause of death in 67% of the patients. An unexpected observation was the finding that active cardiopulmonary disease accounted for 37% of deaths. Although late mortality from degenerative vascular disease is being increasingly reported with the modern prolonged SLE survivorship, it was identified in only one patient. We conclude that active disease remains the most important factor in mortality in SLE.
M G Cohen; E K Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  22     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Princess Alexandra Hospital, Brisbane, Qld., NSW, Australia.
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MeSH Terms
Cardiovascular Diseases / mortality
Kidney Diseases / mortality
Lupus Erythematosus, Systemic / complications,  mortality*
Middle Aged
Sepsis / mortality

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