Document Detail

Mortality in hypoplastic left heart syndrome: Review of 216 autopsy cases of aortic atresia with attention to coronary artery disease.
MedLine Citation:
PMID:  22498086     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Aortic atresia (AA) in hypoplastic left heart syndrome (HLHS) has been associated with increased mortality in several prior studies. We reviewed our autopsy series to explore the relationship of coronary abnormalities to anatomic subsets of HLHS with AA. METHODS: We retrospectively reviewed all pathology specimens with AA/MS (mitral stenosis) and AA/MA (mitral atresia) in the Cardiac Registry of Children's Hospital Boston between 1955 and 2009 including autopsy reports, operative notes, and imaging studies. Formalin-fixed hearts were examined, and cases found to have macroscopic coronary artery abnormalities were sectioned at mid-left ventricular level in the transverse plane and at mid-right ventricular level in the longitudinal plane for histologic analysis of coronary arteries using tissue sections stained with hematoxylin and eosin. RESULTS: A total of 216 autopsy cases were identified with AA/MS (134) and AA/MA (82). Coronary anomalies were found in 49 cases, left ventricle-coronary fistula in 39, all in AA/MS, and 10 other coronary abnormalities, all in AA/MA. Histologic study confirmed fistulas only in the AA/MS group with no evidence of fistulas in the AA/MA group. CONCLUSIONS: The occurrence of left ventricle-coronary fistulas appears limited to the AA/MS group, and coronary fistula specimens were disproportionately more prevalent in postoperative specimens. Further clinical studies are required to validate this finding and to identify subgroups that carry a higher mortality risk.
Meena Nathan; Alex K Williamson; John E Mayer; Emile A Bacha; Amy L Juraszek
Related Documents :
8311596 - Intraoperative electromagnetic flowmeter measurements in coronary artery bypass grafts.
9914466 - Anterior ischemic optic neuropathy: a complication after extracorporal circulation.
3492976 - Atheroembolic perioperative infarction during repeat coronary bypass surgery: angiograp...
21128566 - Torsades de pointes and acute de novo heart failure in a young woman.
22998856 - Prospective randomized comparison of conventional stress echocardiography and real-time...
3155456 - Comparative cost of myocardial revascularization: percutaneous transluminal angioplasty...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  -     ISSN:  1097-685X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Department of Cardiac Surgery, Children's Hospital Boston and Harvard Medical School, Boston, Mass.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optimization of mediastinal staging in potential candidates for stereotactic radiosurgery of the che...
Next Document:  Evolving surgical techniques for pulmonary endarterectomy according to the changing features of chro...