Document Detail

Mortality from thyroid cancer in patients with hyperthyroidism: the Theagenion Cancer Hospital experience.
MedLine Citation:
PMID:  18819945     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyroid carcinoma has been reported in patients operated for different types of hyperthyroidism and the probability of a hot nodule being malignant seems to be low. The aim of the present study was to explore the relationship between thyroid cancer, hyperthyroidism and outcome in a large cohort of patients who presented to a tertiary cancer centre in Northern Greece. PATIENTS: Among 720 patients treated for thyroid cancer, 60 had a concomitant diagnosis of hyperthyroidism due to Graves' disease (n=14), solitary autonomous adenoma (n=17), or multinodular goiter (n=29). Adverse prognostic factors were common in patients with a previous history of hyperthyroidism at the time of diagnosis of thyroid cancer, including cases where the cancer was discovered coincidentally after thyroid surgery for hyperthyroidism and cases where tumor size was more than 10 mm. RESULTS: In 10 out of 17 patients with hyperthyroidism due to solitary autonomous adenomas, the tumor was located within the hot nodule and two of these patients developed local and distant metastases and died from the disease 4 and 15 years after thyroidectomy. CONCLUSION: Clinicians managing patients with hyperthyroidism need to be aware of the possible increased risk of thyroid cancer in this patient group.
Kalliopi Pazaitou-Panayiotou; Petros Perros; Maria Boudina; George Siardos; Apostolos Drimonitis; Frideriki Patakiouta; Iraklis Vainas
Related Documents :
10229925 - Low sensitivity of the sister chromatid exchange assay to detect the genotoxic effects ...
21082735 - Microrna-206 is associated with invasion and metastasis of lung cancer.
20230995 - Braf mutation in papillary thyroid carcinoma: pathogenic role and clinical implications.
15950715 - Primary thyroid cancer after a first tumour in childhood (the childhood cancer survivor...
23322675 - Increased cancer burden among pesticide applicators and others due to pesticide exposure.
15346355 - Does administration of isosorbide mononitrate affect cellular proliferation in oral squ...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-26
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  159     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM    
Department of Endocrinology-Endocrine Oncology, Theagenion Cancer Hospital, 2, Alexandrou Simeonidi Street, 54007 Thessaloniki, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cohort Studies
Follow-Up Studies
Hospital Mortality / trends*
Hyperthyroidism / complications*,  mortality*,  pathology
Middle Aged
Oncology Service, Hospital / trends
Thyroid Neoplasms / complications*,  mortality*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Problems with GH assays and strategies toward standardization.
Next Document:  Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothal...