Document Detail


Mortality from thyroid cancer in patients with hyperthyroidism: the Theagenion Cancer Hospital experience.
MedLine Citation:
PMID:  18819945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Thyroid carcinoma has been reported in patients operated for different types of hyperthyroidism and the probability of a hot nodule being malignant seems to be low. The aim of the present study was to explore the relationship between thyroid cancer, hyperthyroidism and outcome in a large cohort of patients who presented to a tertiary cancer centre in Northern Greece. PATIENTS: Among 720 patients treated for thyroid cancer, 60 had a concomitant diagnosis of hyperthyroidism due to Graves' disease (n=14), solitary autonomous adenoma (n=17), or multinodular goiter (n=29). Adverse prognostic factors were common in patients with a previous history of hyperthyroidism at the time of diagnosis of thyroid cancer, including cases where the cancer was discovered coincidentally after thyroid surgery for hyperthyroidism and cases where tumor size was more than 10 mm. RESULTS: In 10 out of 17 patients with hyperthyroidism due to solitary autonomous adenomas, the tumor was located within the hot nodule and two of these patients developed local and distant metastases and died from the disease 4 and 15 years after thyroidectomy. CONCLUSION: Clinicians managing patients with hyperthyroidism need to be aware of the possible increased risk of thyroid cancer in this patient group.
Authors:
Kalliopi Pazaitou-Panayiotou; Petros Perros; Maria Boudina; George Siardos; Apostolos Drimonitis; Frideriki Patakiouta; Iraklis Vainas
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-26
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  159     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM    
Affiliation:
Department of Endocrinology-Endocrine Oncology, Theagenion Cancer Hospital, 2, Alexandrou Simeonidi Street, 54007 Thessaloniki, Greece. kpazaitou@in.gr
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MeSH Terms
Descriptor/Qualifier:
Aged
Cohort Studies
Female
Follow-Up Studies
Hospital Mortality / trends*
Humans
Hyperthyroidism / complications*,  mortality*,  pathology
Male
Middle Aged
Oncology Service, Hospital / trends
Thyroid Neoplasms / complications*,  mortality*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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