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Mortality from cancers of the extra-thoracic airways in relation to radon progeny in the WISMUT cohort, 1946-2008.
MedLine Citation:
PMID:  24678796     Owner:  NLM     Status:  Publisher    
Abstract Purpose: Inhalation of radon progeny can cause high lung and respiratory tract radiation doses. The aim of this paper is to examine the relationship between radon progeny and cancers of the extra-thoracic airways in the German uranium miner cohort for an extended follow-up through 2008. Methods: The cohort includes 58,690 workers employed between 1946 and 1989 at the Wismut company. Exposure to radon progeny in Working Level Months (WLM) was determined from a comprehensive job-exposure matrix. The mean (max) cumulative exposure to radon among exposed cohort members (86%) was 280 WLM (3,224 WLM). Internal Poisson regression models were applied to estimate the linear Excess Relative Risk (ERR) per unit of cumulative exposure to radon. Results: A small increase in the mortality from all cancers of the extra-thoracic airways combined with increasing cumulative exposure to radon was found (ERR/100 WLM = 0.036, p=0.12), based on 234 deaths. The estimated ERR's per 100 WLM for relevant cancer sub-groups were: 0.017 (p>0.5) larynx (n=94); 0.077 (p=0.20) pharynx (n=74); and 0.030 (p>0.5) tongue and mouth (n=55). Conclusion: Results indicate a small but not statistically significant increase in mortality from cancers of the extra-thoracic airways in relation to radon. Low statistical power and uncontrolled confounding are limitations of this study.
M Kreuzer; F Dufey; J Marsh; D Nowak; M Schnelzer; L Walsh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-28
Journal Detail:
Title:  International journal of radiation biology     Volume:  -     ISSN:  1362-3095     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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