| Mortality and cholesterol metabolism in familial hypercholesterolemia. Long-term follow-up of 96 patients. | |
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MedLine Citation:
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PMID: 3348758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this prospective study was to explore the association of different prognostic factors including parameters of cholesterol metabolism with coronary morbidity and mortality in a study group of 96 patients who were heterozygous for familial hypercholesterolemia. During a 15-year follow-up period, 27% of the patients (44% of the men and 10% of the women, p less than 0.01) died from coronary disease, and an additional 4% died of noncoronary causes. Of the baseline characteristics, male gender, previous myocardial infarction, and smoking were the classical risk factors significantly associated with poor cardiac prognosis. In addition, a low bile acid synthesis predicted enhanced coronary mortality both in univariate and multivariate analysis, and in men bile acid synthesis was significantly correlated with cardiac mortality. Further analysis indicated that also in subjects without baseline myocardial infarction, low bile acid, cholesterol synthesis, or both predicted increased risk of coronary events. In multivariate analysis, male gender, previous myocardial infarction, and low bile acid synthesis at baseline explained 5%, 15%, and 5% (25%), respectively, of the variability of survival. Age, serum total cholesterol, and triglyceride values were unrelated to survival. |
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Authors:
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T A Miettinen; H Gylling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arteriosclerosis (Dallas, Tex.) Volume: 8 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1988 Mar-Apr |
Date Detail:
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Created Date: 1988-04-21 Completed Date: 1988-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-7 Citation Subset: IM |
Affiliation:
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Second Department of Medicine, University of Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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etiology,
mortality Female Follow-Up Studies Humans Hyperlipoproteinemia Type II / complications, metabolism*, mortality Male Middle Aged Prospective Studies |
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