| Mortality and cancer incidence in workers in two Australian prebake aluminium smelters. | |
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MedLine Citation:
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PMID: 19218259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exposures in the aluminium production industry have been declining and this study aimed to investigate cancer and mortality in two Australian prebake aluminium smelters. METHODS: The cohort included 4396 males who had worked in a prebake smelter for at least 3 months. They were matched against the National Death Index and the National Cancer Statistics Clearing House to obtain cause of death and type of cancer. Standardised Mortality Ratios (SMRs) and Standardised Incidence Ratios (SIRs) were calculated for the whole cohort, for production or maintenance work categories and for duration of employment categories. RESULTS: The SMRs for all causes, circulatory, respiratory and injury deaths were at or below expected. Mesothelioma was the only significantly increased cause of death (SMR 3.52, 95% CI 1.47 to 8.46). Death from prostate cancer in production workers was elevated (SMR 2.39, 95% CI 1.29 to 4.44) and in those who had worked for more than 20 years in production or maintenance jobs (SMR 3.67, 95% CI 1.53 to 8.81). There were statistically significant excesses of incident stomach cancer, mesothelioma, and kidney cancer cases, while the SIR for melanoma was significantly reduced. There was no significant trend for duration of exposure for any type of incident cancer. CONCLUSIONS: This study found no overall excess of mortality or cancer, but incident mesothelioma and kidney cancer risks were elevated. The lack of excess risk for lung or bladder cancer or deaths from respiratory disease may be related to the different level and pattern of exposure between Søderberg and prebake smelters. |
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Authors:
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M R Sim; A Del Monaco; J L Hoving; E Macfarlane; D McKenzie; G Benke; N de Klerk; L Fritschi |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-02-12 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 66 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 464-70 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. malcolm.sim@med.monash.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aluminum / toxicity* Female Humans Incidence Male Metallurgy Middle Aged Neoplasms / epidemiology, mortality* Occupational Diseases / epidemiology, mortality* Victoria / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
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7429-90-5/Aluminum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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