Document Detail

Mortality and atrial fibrillation: is there a causal relationship?
MedLine Citation:
PMID:  19367229     Owner:  NLM     Status:  MEDLINE    
Almost all studies show that atrial fibrillation (AF) is associated with increased mortality. What is less certain is whether this association is a straightforward cause-and-effect relationship, or if AF is merely a marker of severity of cardiovascular disease(s) or the aging process. AF can lead to the worsening of left ventricular filling, contribute to loss of atrioventricular synchrony, affect cardiac remodeling, and even cause a tachycardia-induced cardiomyopathy. AF could be a marker for underlying atherosclerotic disease that itself determines mortality, or the increased oxygen consumption associated with an increasing ventricular rate may lead to ischemia secondary to increased myocardial consumption and precipitate acute coronary syndromes. Although it is generally accepted that the stasis of atrial blood in AF promotes clot formation, studies have shown increases in specific coagulation factors-all of which have the ability to increase morbidity and/or mortality through their elevations. Another possibility is that AF is not the cause of the hypercoagulable state, but is instead a marker of such a state.
Howard Levitt; Neil L Coplan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  10     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-15     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-8     Citation Subset:  IM    
Division of Cardiovascular Medicine, Department of Medicine, Lenox Hill Hospital, New York, NY, USA.
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MeSH Terms
Atrial Fibrillation / complications,  mortality*,  physiopathology
Blood Coagulation
Cardiomyopathies / etiology,  mortality
Myocardial Ischemia / etiology,  mortality
Oxygen Consumption
Risk Assessment
Risk Factors
Ventricular Function, Left
Ventricular Remodeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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