| Mortality and atrial fibrillation: is there a causal relationship? | |
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MedLine Citation:
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PMID: 19367229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Almost all studies show that atrial fibrillation (AF) is associated with increased mortality. What is less certain is whether this association is a straightforward cause-and-effect relationship, or if AF is merely a marker of severity of cardiovascular disease(s) or the aging process. AF can lead to the worsening of left ventricular filling, contribute to loss of atrioventricular synchrony, affect cardiac remodeling, and even cause a tachycardia-induced cardiomyopathy. AF could be a marker for underlying atherosclerotic disease that itself determines mortality, or the increased oxygen consumption associated with an increasing ventricular rate may lead to ischemia secondary to increased myocardial consumption and precipitate acute coronary syndromes. Although it is generally accepted that the stasis of atrial blood in AF promotes clot formation, studies have shown increases in specific coagulation factors-all of which have the ability to increase morbidity and/or mortality through their elevations. Another possibility is that AF is not the cause of the hypercoagulable state, but is instead a marker of such a state. |
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Authors:
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Howard Levitt; Neil L Coplan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in cardiovascular medicine Volume: 10 ISSN: 1530-6550 ISO Abbreviation: Rev Cardiovasc Med Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-15 Completed Date: 2009-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960007 Medline TA: Rev Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 25-8 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Department of Medicine, Lenox Hill Hospital, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Fibrillation
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complications,
mortality*,
physiopathology Blood Coagulation Cardiomyopathies / etiology, mortality Female Humans Male Myocardial Ischemia / etiology, mortality Oxygen Consumption Risk Assessment Risk Factors Ventricular Function, Left Ventricular Remodeling |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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