Document Detail


Mortality among offspring of women diagnosed with cancer: A population-based cohort study.
MedLine Citation:
PMID:  23047289     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
One in five cancers in women is diagnosed prior to and during a woman's fertile years. This study evaluates mortality risks in offspring of mothers with history of cancer. From the Swedish Multi-generation Register and the Cancer Register we identified all 174,893 children whose mother had been diagnosed with cancer between 1958 and 2001. We categorized offspring into those born before (>1 year before), around (within 1 year before and after diagnosis), and after (>1 year after) their mother's cancer diagnosis and compared their risks of death (Standardised Mortality Ratios, SMRs) and causes of death with the background population. Overall, offspring of mothers diagnosed with cancer had no increased mortality risk (SMR 1·00; 95% Confidence Interval [CI] 0·97 to 1·03). Increased mortality risks were seen in offspring of mothers with tobacco-related cancers (head and neck, thoracic, cervical) (SMR 1·23; 95% CI 1·13 to 1·33), in children born around their mother's diagnosis (SMR 1·66; 95% CI 1·25 to 2·13), and in children born after their mother's hematopoietic cancer diagnosis (SMR 2·07; 95% CI 1·10 to 3·35). Compared to the background population, children born around their mother's diagnosis were more likely to die of congenital and perinatal conditions. Overall, offspring of women diagnosed with cancer were not at increased risk of death, except for certain subgroups. Timing of pregnancy in relation to diagnosis and cancer site modifies mortality risks in the offspring. © 2012 Wiley Periodicals, Inc.
Authors:
Helena M Verkooijen; Joella X Ang; Jenny Liu; Kamila Czene; Agus Salim; Mikael Hartman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 UICC.
Affiliation:
Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Imaging Division, University Medical Center Utrecht, the Netherlands.
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