| Mortality after transfusions, relation to donor sex. | |
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MedLine Citation:
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PMID: 21477152 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction Blood products from female donors have been associated with worse outcome after blood transfusions. We aimed to quantify the association of overall mortality with transfusions from female blood donors. Methods We performed a cohort study of all transfusion recipients during a 5-year period at the Leiden University Medical Center. Analyses were performed in a sub-cohort of recipients with all transfusions from donors of the same sex. Effects in male and female recipients were analysed both separately and averaged, for an overall estimate. Results Overall, when averaged over both male and female recipients, transfusions from female donors were not associated with increased mortality. However, in male recipients transfusions from female donors were positively associated with mortality, while in female recipients the association was reversed. The hazard ratio for mortality after sex-mismatched transfusions was 1·2 (95% CI, 0·98-1·4). In recipients aged 1-55 it was 1·8 (95% CI, 1·2-2·7). In recipients over 55, with more other risk factors for mortality, it was 1·0 (95% CI, 0·83-1·2). Conclusions Overall transfusions from female donors were not associated with increased mortality. However, male recipients of blood from female donors did have an increased risk of death. Female recipients of blood from male donors showed a weaker increase in mortality. |
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Authors:
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R A Middelburg; E Briët; J G van der Bom |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
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Title: Vox sanguinis Volume: - ISSN: 1423-0410 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Author(s). Vox Sanguinis © 2011 International Society of Blood Transfusion. |
Affiliation:
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Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Sanquin Research Leiden, and Jon J. van Rood Center for Clinical Transfusion Research, Leiden University Medical Center, Leiden, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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