Document Detail

Mortality risk among preterm babies: immaturity versus underlying pathology.
MedLine Citation:
PMID:  20407380     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Deaths among preterm births are presumably due to both immaturity and the conditions that cause preterm birth. Their relative contributions are unknown.
METHODS: Using US birth certificates (1995-2002), we estimated what portion of preterm neonatal mortality may be attributable to immaturity alone. Twins have elevated mortality, yet they usually have lower mortality than singletons at most preterm weeks. Twinning itself is a cause of early birth. Thus, at any given preterm week, singletons are more likely than twins to have pathologic causes of preterm delivery. If any such cause is associated with a mortality risk higher than that conferred by twinning, it is possible for singletons to have higher mortality than twins at some preterm weeks. Thus, mortality of twins at those weeks comes closer to describing the risk due to immaturity itself. To exclude high-risk babies, we focused on singletons and twins least likely to have suffered fetal growth disruptions (ie, those with "optimal" birth weight). At each gestational week from 24 to 36, we identified (for twins and singletons separately) the 500-gram weight category with the lowest neonatal mortality, and selected the lower of the 2 mortality rates.
RESULTS: Using the above as our best estimates of mortality due to immaturity alone, we calculated that about half the mortality of singleton preterm babies was due to the pathologies that cause early delivery.
CONCLUSIONS: Factors that cause preterm birth apparently contribute a large proportion of preterm mortality. If so, the prevention of preterm mortality requires more than the postponement of delivery.
Olga Basso; Allen Wilcox
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  21     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-09-22     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-7     Citation Subset:  IM    
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
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MeSH Terms
Gestational Age
Infant Mortality*
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / mortality*
Risk Factors
United States / epidemiology
Grant Support

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