| Mortality of Parkinson's disease by Hoehn-Yahr stage from community-based and clinic series [Keelung Community-based Integrated Screening (KCIS) no. 17)]. | |
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MedLine Citation:
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PMID: 19674213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We aimed to quantify the mortality reduction by which the early detection of Parkinson's disease (PD) within a community-based study could reduce the number of advanced cases. METHODS: Data used in this study were derived from two community-based surveys and from a clinical series of PD cases identified from a medical centre. The cumulative survival by Hoehn-Yahr (H-Y) scale was estimated and the mortality reduction derived from a community-based survey was predicted. RESULTS: A total of 117 PD patients were detected through two community-based approaches. By comparing the H-Y stage distribution of screen-detected cases with those from the clinical series, a 22.5% excess in the number of early PD (H-Y stage I and stage II) were identified with screening. The risk ratios of being H-Y stage III or severe for community-based detected cases versus clinical series were 0.49 (95% confidence interval: 0.30-0.78). The total death rate adjusted by H-Y stage distribution was 21% and 28% for cases from community and clinical series, respectively. CONCLUSIONS: The present study revealed that early detection of PD through a community-based survey may reduce 51% incidence of stage III or more severe PD at diagnosis, leading to a 25% reduction in mortality. |
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Authors:
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Horng-Huei Liou; Chia-Yun Wu; Yueh-Hsia Chiu; Amy Ming-Fang Yen; Rong-Chi Chen; Ta-Fu Chen; Chih-Chuan Chen; Yuarn-Chung Hwang; Ying-Rong Wen; Tony Hsiu-Hsi Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of evaluation in clinical practice Volume: 15 ISSN: 1365-2753 ISO Abbreviation: J Eval Clin Pract Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-13 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609066 Medline TA: J Eval Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 587-91 Citation Subset: IM |
Affiliation:
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Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Academic Medical Centers Adult Aged Early Diagnosis* Female Health Care Surveys Humans Male Mass Screening* Middle Aged Mortality / trends* Parkinson Disease / classification, diagnosis*, etiology, mortality* Proportional Hazards Models Severity of Illness Index Survival Analysis Taiwan / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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