| Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS. | |
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MedLine Citation:
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PMID: 19818505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of drug-resistant cytomegalovirus (CMV) on survival among patients with CMV retinitis. DESIGN: Prospective cohort study during 1993 to 2003. PARTICIPANTS: We included 266 patients with AIDS and newly diagnosed CMV retinitis treated with either ganciclovir or foscarnet. METHODS: Data on ganciclovir and foscarnet resistance were obtained from blood and urine specimens collected at regular, predetermined intervals. The effect of resistant CMV on mortality was evaluated with a time-dependent Cox proportional hazard model. MAIN OUTCOME MEASURES: Mortality. RESULTS: The median survival of the entire cohort was 12.6 months. Analysis of risk factors for mortality demonstrated that resistant CMV was associated with an increased mortality (hazard ratio, 1.65; 95% confidence interval, 1.05-2.56; P = 0.032). Among the other parameters tested, only time since AIDS diagnosis was associated significantly with mortality, with a hazard ratio of 1.10 per year since AIDS diagnosis (P = 0.001). CONCLUSIONS: Resistant CMV is associated with increased mortality among patients with AIDS being treated for CMV retinitis. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references. |
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Authors:
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Douglas A Jabs; Barbara K Martin; Michael S Forman; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-08 |
Journal Detail:
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Title: Ophthalmology Volume: 117 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-02-18 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 128-132.e2 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ophthalmology, The Johns Hopkins University School of Medicine.douglas.jabs@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy,
mortality*,
virology Adult Antiretroviral Therapy, Highly Active Antiviral Agents / therapeutic use* Cytomegalovirus / isolation & purification, physiology* Cytomegalovirus Retinitis / drug therapy, mortality*, virology Drug Resistance, Viral* Female Foscarnet / therapeutic use Ganciclovir / therapeutic use Humans Male Proportional Hazards Models Prospective Studies Survival Rate Time Factors Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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EY-10268/EY/NEI NIH HHS; EY-15643/EY/NEI NIH HHS; M01 RR000052-440863/RR/NCRR NIH HHS; M01-RR00052/RR/NCRR NIH HHS; R01 EY010268-10/EY/NEI NIH HHS; R03 EY015643-02/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 4428-95-9/Foscarnet; 82410-32-0/Ganciclovir |
| Investigator | |
Investigator/Affiliation:
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Douglas A Jabs / ; John G Bartlett / ; Diane M Brown / ; Lisa M Brune / ; J P Dunn / ; Richard D Semba / ; Jennifer E Thorne / ; Stephen G Bolton / ; John H Kempen / ; Paul A Latkany / ; Susan M LaSalvia / ; Tracey Miller / ; Earline Nanan / ; Quan Dong Nguyen / ; Laura G Neisser / ; Eva Rorer / ; George Peters / ; Qazi Faquir / ; Armando Oliver / ; David V Weinberg / ; Alice T Lyon / ; Annie Muñana / ; Lori Kaminski / ; Janet L Davis / ; Elias Mavofrides / ; Elizabeth Fuentes / ; Elizabeth Cruz / ; Tina A Rhee / ; Patricia Vera / ; Barbara K Martin / ; Michelle O Ricks / ; Lynn M Hutt / ; Cheryl Enger / ; Shirley Quaskey / ; Judy Southall / ; Joseph B Margolick / ; Fred Menendez / ; Matthew D Davis / ; Larry Hubbard / ; Jane Armstrong / ; Dolores Hurlburt / ; Sheri Glaeser / ; Jeff Joyce / ; Linda Kastorff / ; Nancy Robinson / ; Marilyn Vanderhoof-Young / ; Jackson J Brooks / ; Michael Forman / ; Linda Gluck / ; Tamica Hamlin / ; Huiling Hu / ; Alicja Rylka / ; Avareena Schools-Cropper / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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