|Mortality of 2009 pandemic influenza A(H1N1) in Germany.|
|PMID: 21163179 Owner: NLM Status: MEDLINE|
|The mortality in Germany caused by the 2009 pandemic influenza A(H1N1) seems to have been one of the lowest in Europe. We provide a detailed analysis of all 252 fatal cases of confirmed infection with the pandemic virus notified between 29 April 2009 and 31 March 2010. The overall mortality was 3.1 (95% confidence interval (CI): 2.7 to 3.5) per one million inhabitants. We observed an increase in the case fatality rate of notified cases over time; notified cases aged 60 years or older had the highest case fatality rate (2.16%; 95% CI: 1.61 to 2.83; odds ratio: 5.4; p<0.001; reference group: 35–59 years). The median delay of four days (interquartile range (IQR): 2–7) between symptom onset and antiviral treatment was significantly longer in fatal cases than for non-fatal cases (median: two days (IQR: 1–3; p<0.001). Analysis of the underlying medical conditions of fatal cases, based on the observed frequency of the conditions in the general population, confirms the risk for fatal outcome, which is most notably due to immunosuppression, diabetes and respiratory diseases. Our results suggest that early treatment might have had an impact on overall mortality. Identification of risk groups for targeted intervention to prevent fatalities needs to take into account the distribution of underlying conditions in the population.|
|H Wilking; S Buda; E von der Lippe; D Altmann; G Krause; T Eckmanns; W Haas|
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|Type: Journal Article Date: 2010-12-09|
|Title: Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin Volume: 15 ISSN: 1560-7917 ISO Abbreviation: Euro Surveill. Publication Date: 2010 Dec|
|Created Date: 2010-12-17 Completed Date: 2011-03-04 Revised Date: 2013-05-01|
Medline Journal Info:
|Nlm Unique ID: 100887452 Medline TA: Euro Surveill Country: Sweden|
|Languages: eng Pagination: - Citation Subset: IM|
|Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.|
|APA/MLA Format Download EndNote Download BibTex|
Antiviral Agents / therapeutic use
Germany / epidemiology
Influenza A Virus, H1N1 Subtype*
Influenza, Human / drug therapy, mortality*, prevention & control
Mortality / trends*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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