Document Detail


Mortality of 2009 pandemic influenza A(H1N1) in Germany.
MedLine Citation:
PMID:  21163179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mortality in Germany caused by the 2009 pandemic influenza A(H1N1) seems to have been one of the lowest in Europe. We provide a detailed analysis of all 252 fatal cases of confirmed infection with the pandemic virus notified between 29 April 2009 and 31 March 2010. The overall mortality was 3.1 (95% confidence interval (CI): 2.7 to 3.5) per one million inhabitants. We observed an increase in the case fatality rate of notified cases over time; notified cases aged 60 years or older had the highest case fatality rate (2.16%; 95% CI: 1.61 to 2.83; odds ratio: 5.4; p<0.001; reference group: 35–59 years). The median delay of four days (interquartile range (IQR): 2–7) between symptom onset and antiviral treatment was significantly longer in fatal cases than for non-fatal cases (median: two days (IQR: 1–3; p<0.001). Analysis of the underlying medical conditions of fatal cases, based on the observed frequency of the conditions in the general population, confirms the risk for fatal outcome, which is most notably due to immunosuppression, diabetes and respiratory diseases. Our results suggest that early treatment might have had an impact on overall mortality. Identification of risk groups for targeted intervention to prevent fatalities needs to take into account the distribution of underlying conditions in the population.
Authors:
H Wilking; S Buda; E von der Lippe; D Altmann; G Krause; T Eckmanns; W Haas
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Publication Detail:
Type:  Journal Article     Date:  2010-12-09
Journal Detail:
Title:  Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin     Volume:  15     ISSN:  1560-7917     ISO Abbreviation:  Euro Surveill.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-17     Completed Date:  2011-03-04     Revised Date:  2013-05-01    
Medline Journal Info:
Nlm Unique ID:  100887452     Medline TA:  Euro Surveill     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Affiliation:
Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Antiviral Agents / therapeutic use
Child
Child, Preschool
Comorbidity
Cross-Sectional Studies
Female
Germany / epidemiology
Humans
Infant
Infant, Newborn
Influenza A Virus, H1N1 Subtype*
Influenza, Human / drug therapy,  mortality*,  prevention & control
Male
Middle Aged
Mortality / trends*
Odds Ratio
Pandemics*
Prevalence
Risk Factors
Sex Distribution
Time Factors
Young Adult
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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