| Morphometry of right ventricular hypertrophy induced by strenuous exercise in rat. | |
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MedLine Citation:
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PMID: 6216815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects on the myocardium, particularly those structural properties of the capillary network relevant to tissue oxygenation, were studied morphometrically in rats subjected to a severe running program. Physical conditioning produced a 31% increase in right ventricular weight and only a 12% increase in the weight of the left ventricle. Quantitative analysis of right ventricular myocardium demonstrated relative decreases in capillary luminal volume density (-27%) and capillary luminal surface density (-20%) and an increase in the average maximum distance from the capillary wall to the mitochondria of myocytes (14%). In contrast, the contractile mass expanded in proportion to the growth of the ventricle through augmentation of the cross-sectional area (17%) and length (19%) of the average myocyte. Evaluation of the subcellular constituents of myocytes showed no change in the mitochondria-to-myofibril volume ratio. In conclusion, the capillary bed controlling oxygen availability, diffusion, and transport suggests that excessive physical activity may be detrimental to the myocardium. |
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Authors:
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P Anversa; C Beghi; V Levicky; S L McDonald; Y Kikkawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 243 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-01-27 Completed Date: 1983-01-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H856-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Capillaries / physiopathology Cardiomegaly / etiology, physiopathology* Coronary Circulation Coronary Vessels / physiopathology Heart / anatomy & histology* Heart Atria / anatomy & histology Organ Size Physical Exertion* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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HL-14713/HL/NHLBI NIH HHS; HL-24479/HL/NHLBI NIH HHS; HL-24817/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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