Document Detail

Morphometry of right ventricular hypertrophy induced by strenuous exercise in rat.
MedLine Citation:
PMID:  6216815     Owner:  NLM     Status:  MEDLINE    
Effects on the myocardium, particularly those structural properties of the capillary network relevant to tissue oxygenation, were studied morphometrically in rats subjected to a severe running program. Physical conditioning produced a 31% increase in right ventricular weight and only a 12% increase in the weight of the left ventricle. Quantitative analysis of right ventricular myocardium demonstrated relative decreases in capillary luminal volume density (-27%) and capillary luminal surface density (-20%) and an increase in the average maximum distance from the capillary wall to the mitochondria of myocytes (14%). In contrast, the contractile mass expanded in proportion to the growth of the ventricle through augmentation of the cross-sectional area (17%) and length (19%) of the average myocyte. Evaluation of the subcellular constituents of myocytes showed no change in the mitochondria-to-myofibril volume ratio. In conclusion, the capillary bed controlling oxygen availability, diffusion, and transport suggests that excessive physical activity may be detrimental to the myocardium.
P Anversa; C Beghi; V Levicky; S L McDonald; Y Kikkawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  243     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H856-61     Citation Subset:  IM    
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MeSH Terms
Body Weight
Capillaries / physiopathology
Cardiomegaly / etiology,  physiopathology*
Coronary Circulation
Coronary Vessels / physiopathology
Heart / anatomy & histology*
Heart Atria / anatomy & histology
Organ Size
Physical Exertion*
Rats, Inbred Strains
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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