Document Detail

Morphometry for the prognosis of acute lymphoblastic leukemia in childhood.
MedLine Citation:
PMID:  3476916     Owner:  NLM     Status:  MEDLINE    
The morphology of acute lymphoblastic leukemia is of prognostic significance, but due to the qualitative subjective nature of the assessment, disagreement between pathologists may be considerable. In order to investigate the adjuvant potential of morphometry, the present study was undertaken. Morphometry was applied in 21 children between 2 and 10 years of age with acute lymphoblastic leukemia (ALL) with a follow-up of at least 5 years. Of these, 9 patients died, 12 (57.1%) survived for at least five years (maximally 12 years). Morphometry appeared to have an important prognostic value, independent of the FAB classification currently in use. Combination of the nuclear-cell area ratio and the cell area gave a rather good discrimination, although these quantitative data from a morphological continuum. The positive results of this pilot study point to the necessity of evaluating the data on a larger material.
P Tosi; P Luzi; C Miracco; R Santopietro; J P Baak; C Bernardini; A Acquaviva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  182     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  416-20     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / pathology
Child, Preschool
Follow-Up Studies
Leukemia, Lymphoid / mortality,  pathology*

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