Document Detail


Morphometry for the prognosis of acute lymphoblastic leukemia in childhood.
MedLine Citation:
PMID:  3476916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The morphology of acute lymphoblastic leukemia is of prognostic significance, but due to the qualitative subjective nature of the assessment, disagreement between pathologists may be considerable. In order to investigate the adjuvant potential of morphometry, the present study was undertaken. Morphometry was applied in 21 children between 2 and 10 years of age with acute lymphoblastic leukemia (ALL) with a follow-up of at least 5 years. Of these, 9 patients died, 12 (57.1%) survived for at least five years (maximally 12 years). Morphometry appeared to have an important prognostic value, independent of the FAB classification currently in use. Combination of the nuclear-cell area ratio and the cell area gave a rather good discrimination, although these quantitative data from a morphological continuum. The positive results of this pilot study point to the necessity of evaluating the data on a larger material.
Authors:
P Tosi; P Luzi; C Miracco; R Santopietro; J P Baak; C Bernardini; A Acquaviva
Related Documents :
23395126 - Potential consequences of low biopsy core number in selection of patients with prostate...
23266036 - Therapy of core binding factor acute myeloid leukemia: incremental improvements toward ...
8116566 - L3 acute lymphoblastic leukemia. comparison with small noncleaved cell lymphoma involvi...
24623566 - Preservation of ipsilateral submandibular gland is ill advised in floor of mouth or ton...
9256886 - Phase i-ii study of combined 5-fluorouracil and cisplatin chemotherapy and altered frac...
23252716 - Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metab...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  182     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  416-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Nucleus / pathology
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Leukemia, Lymphoid / mortality,  pathology*
Male
Prognosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dermatitis artefacta of the paraoral region.
Next Document:  Incomplete Reiter's syndrome following chemotherapy of acute myeloid leukaemia.