Document Detail

Morphometry of buccal mucosal cells in fluorosis--a new paradigm.
MedLine Citation:
PMID:  21406483     Owner:  NLM     Status:  MEDLINE    
STUDY BACKGROUND: Fluorosis is one of the manifestations of chronic poisoning from long-term exposure to high levels of fluoride. An estimated 62 million people in 17 states in India are affected with dental and skeletal fluorosis.
OBJECTIVE: To evaluate the cytological morphology of exfoliated oral mucosal cells among various stages of fluorosis patients compared with controls.
DESIGN AND METHODS: Exfoliative cytology PAP-stained smears of 21 cases of fluorosis and 21 controls subjected to morphometric analysis using image Proplus software. For the assessment parameters like maximum and minimum diameter of the nucleus, cell and perimeter of the cell and nucleus were considered.
RESULTS: An increase in maximum and minimum diameter of nucleus, perimeter of nucleus and cell in cases when compared to controls.
CONCLUSIONS: Fluorosis induces oxidative stress, DNA damage and apoptosis which can be the reasons for the increase in the nuclear size and decrease in the cell size. Community dental and medical programmes should be stringently implemented in fluorosis-endemic areas, to create awareness regarding the toxic effects of fluoride to the body, especially within the oro-facial region.
S Madusudan Rao; H J Sherlin; N Anuja; R Pratibha; P Priya; T Chandrasekar
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Publication Detail:
Type:  Journal Article     Date:  2011-03-15
Journal Detail:
Title:  Human & experimental toxicology     Volume:  30     ISSN:  1477-0903     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-25     Completed Date:  2012-02-27     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1761-8     Citation Subset:  IM    
Department of Oral and Maxillofacial Pathology, College of Dental Surgery, Saveetha University, Velappanchavadi, Chennai, India.
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MeSH Terms
Case-Control Studies
Cell Nucleus Size
Cell Size
Fluoride Poisoning / pathology*
Fluorosis, Dental / pathology*
Mouth Mucosa / pathology*

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