| Morphometry MRI in the differential diagnosis of parkinsonian syndromes. | |
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MedLine Citation:
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PMID: 20602031 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates the diagnostic value of morphometric magnetic resonance imaging (MRI) in the differential diagnosis among Parkinson's disease (PD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We studied 21 PD cases, 11 MSA-c, 8 MSA-p and 20 PSP cases. Midbrain area (Ams), pons area (Apn), middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP) were measured using MRI. Comparisons were made between PD, MSA-p, MSA-c and PSP. Apn, MCP and SCP morphometry dimensions presented differences among groups. Ams below 105 mm(2) and SCP smaller than 3 mm were the most predictive measures of PSP (sensitivity 95.0 and 80.0%, respectively). For the group of MSA-c patients, Apn area below 315 mm(2) showed good specificity and positive predictive value (93.8% and 72.7%, respectively). In conclusion, dimensions and cut off values obtained from routine MRI can differentiate between PD, PSP and MSA-c with good sensitivity, specificity and accuracy. |
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Authors:
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Rômulo L Gama; Daniel F G Távora; Rodrigo C Bomfim; Cruiff E Silva; Veralice M de Bruin; Pedro F de Bruin |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 68 ISSN: 1678-4227 ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 333-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, Sarah Network of Hospitals for Rehabilitation, Fortaleza, CE, Brazil. romuloggama@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cross-Sectional Studies Diagnosis, Differential Female Humans Magnetic Resonance Imaging / methods* Male Mesencephalon / pathology* Middle Aged Multiple System Atrophy / diagnosis*, pathology Parkinson Disease / diagnosis*, pathology Predictive Value of Tests Sensitivity and Specificity Supranuclear Palsy, Progressive / diagnosis*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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