Document Detail


Morphometry analysis of lymphatics in pulmonary adenocarcinomas with a lepidic growth pattern.
MedLine Citation:
PMID:  23686364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymph vessels play an important role in tumor progression. Pulmonary adenocarcinomas, accounting for half of non-small-cell lung carcinomas, compose a spectrum of histological types, exclusively or without a lepidic growth pattern (LGP) along preserved interalveolar septa. In that context, this study was designed to investigate the lymphatic vascular pattern associated with LGP and the concomitant invasive component of pulmonary adenocarcinomas. Using the D2-40 monoclonal antibody as a marker of lymphatic endothelial cells, the lymphatic vessel density (LVD) and vessel-area fraction (LVAF) were morphometrically analyzed in four adenocarcinomas in situ (AIS) and the LGP of eight invasive adenocarcinomas (LPIA), and compared with their invasive pattern (IPIA). LVD in AIS (2.1 ± 0.7 mm(-2)) and LPIA (2.4 ± 1 mm(-2)) were significantly lower than that in IPIA (14.9 ± 13.6 mm(-2)) (p=0.001). Moreover, the lymphatic vascular pattern in LGP was similar to that of normal lung, with isolated small lymphatic vessels within the interalveolar septa. Our results showing the scarcity of lymphatics in LGP suggest an absence of septal lymphangiogenesis associated with the LGP pattern in lung adenocarcinomas, which could explain, at least partially, the better prognosis observed in tumors with exclusive or predominant lepidic spread compared with other subtypes.
Authors:
Aurélie Sannier; Marianne Kambouchner; Claire Danel; Patrice Callard; Jean-François Bernaudin
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Publication Detail:
Type:  Journal Article     Date:  2013-05-16
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  61     ISSN:  1551-5044     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-26     Completed Date:  2013-09-25     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  571-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology*
Adult
Aged
Cell Division
Female
Humans
Lung Neoplasms / pathology*
Lymphatic Vessels / pathology*
Male
Middle Aged
Neoplasm Invasiveness
Young Adult
Comments/Corrections

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