| Morphometrical and microdensitometrical studies on phenylethanolamine-N-methyltransferase- and neuropeptide Y-immunoreactive neurons in the rostral medulla oblongata of the adult and old male rat. | |
| | |
MedLine Citation:
|
PMID: 3173685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present paper the neuronal systems of the medulla oblongata containing phenylethanolamine-N-methyltransferase- and neuropeptide Y-like immunoreactivity have been characterized in adult (3-month-old) and old (24-month-old) male rats. The phenylethanolamine-N-methyltransferase and neuropeptide Y-immunoreactive neurons have been visualized by means of immunocytochemistry (peroxidase-antiperoxidase technique) and analysed in a quantitative fashion by means of morphometrical (phenylethanolamine-N-methyltransferase- and neuropeptide Y-immunoreactive cell groups) and microdensitometrical (phenylethanolamine-N-methyltransferase-immunoreactive cell groups) approaches developed on the IBAS II image analyser (Zeiss-Kontron). During aging there is (a) a reduction in the area covered by the phenylethanolamine-N-methyltransferase-immunoreactive neuropil for both the C1 and C2 adrenaline cell groups; (b) a reduction in the area covered by the phenylethanolamine-N-methyltransferase-immunoreactive cell bodies, which is highly significant only for the C2 cell group; (c) a decrease in the area covered by the phenylethanolamine-N-methyltransferase-positive cell cluster for both C1 and C2 cell groups; (d) a decrease in the degree of phenylethanolamine-N-methyltransferase immunoreactivity present in the C1 and C2 cell groups; (e) a decay of neuropeptide Y immunoreactivity in the C1 and C2 groups, while the C3 group is unaffected by aging as evaluated by number of phenylethanolamine-N-methyltransferase- and neuropeptide Y-immunoreactive cell body profiles. These results indicate heterogeneities in the responses of the adrenaline-neuropeptide Y cell groups to the aging process. The possible functional consequences of aging-induced changes in the cardiovascular adrenergic neurons are discussed, especially in relation to development of hypertension. |
| | |
Authors:
|
L F Agnati; K Fuxe; M Zoli; I Zini; A Härfstrand; G Toffano; M Goldstein |
Related Documents
:
|
15529005 - Establishment of life-span extended bovine fibroblast cells carrying the characterizati... 19627195 - Water dropwort (ostericum sieboldii) and sedum (sedum sarmentosum) delay h(2)o(2)-induc... 16404345 - Latent membrane protein-1 of epstein - barr virus increases sensitivity to arsenic trio... 3086635 - Do immature t cells accumulate in advanced age? 19098425 - Insulin-like growth factor-1 inhibits sts-induced cell death and increases functional r... 8060615 - Globose basal cells are neuronal progenitors in the olfactory epithelium: a lineage ana... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuroscience Volume: 26 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1988 Aug |
Date Detail:
|
Created Date: 1988-11-23 Completed Date: 1988-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 461-78 Citation Subset: IM |
Affiliation:
|
Department of Human Physiology, University of Modena, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
metabolism* Animals Epinephrine / metabolism*, physiology Image Processing, Computer-Assisted Immunohistochemistry Male Medulla Oblongata / metabolism*, physiology Neuropeptide Y / metabolism*, physiology Phenylethanolamine N-Methyltransferase / metabolism*, physiology Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
|
MH25504/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neuropeptide Y; 51-43-4/Epinephrine; EC 2.1.1.28/Phenylethanolamine N-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Connections to the lateral posterior-pulvinar thalamic complex from the reticular and ventral latera...
Next Document: Morphometrical and microdensitometrical studies on phenylethanolamine-N-methyltransferase- and neuro...