| Morphometric study of the guinea pig small intestine during development. | |
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MedLine Citation:
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PMID: 14988918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mucosal surface area of the guinea pig duodenum, jejunum, and ileum was determined during development, in three age groups: 1-day-old and 2- and 12-week-old animals. The morphometric analysis was performed at three magnification levels. The nominal surface area was determined at the macroscopic level, from intestinal length and perimeter. Villus and microvillus amplification factors were estimated at light-microscopic and transmission electron-microscopic levels, respectively. We found: (1) an increase in the nominal surface area that is maximal in the ileum (7.7-fold); (2) an increase in the villus amplification factor in the duodenum (1.4-fold) and a decline in the jejunum and ileum (0.8-fold), although in the jejunum villus dimensions rise; and (3) a similar increase in the microvillus amplification factor in the three segments (1.1- to 1.4-fold). In conclusion, the total mucosal surface area increased from day 1 to week 12, by 3-fold in the duodenum and jejunum and by 8-fold in the ileum. Regionally, the jejunum shows the largest mucosal surface area, followed by the ileum, and, finally, the duodenum. |
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Authors:
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Montserrat Mitjans; Ruth Ferrer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microscopy research and technique Volume: 63 ISSN: 1059-910X ISO Abbreviation: Microsc. Res. Tech. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-27 Completed Date: 2004-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203012 Medline TA: Microsc Res Tech Country: United States |
Other Details:
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Languages: eng Pagination: 206-14 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Department de Fisiologia-Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Guinea Pigs / anatomy & histology* Intestinal Mucosa / growth & development, ultrastructure Intestine, Small / growth & development*, ultrastructure Male Microscopy, Electron |
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