Document Detail

Morphometric and immunohistochemical investigation of oral epithelial dysplasia and squamous cell carcinoma.
MedLine Citation:
PMID:  2519286     Owner:  NLM     Status:  MEDLINE    
Morphometric assessment including epithelial indices which express morphological features of the epithelium, mitotic index, mean nuclear area, mean form factor of the nucleus and cellular infiltration in the stroma was performed in 14 cases with oral non-dysplastic epithelium and 66 cases with dysplastic epithelium. The results from morphometry showed a close relationship to the histological severity of dysplasia determined by the histological criteria of Bánóczy. Immunohistochemical localization of carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and epidermal growth factor (EGF) were investigated in 14 cases of non-dysplastic epithelium, 66 cases of dysplastic epithelium and 16 cases of squamous cell carcinoma, and compared with the morphometric results. Positive rates of CEA and EMA reaction in epithelial dysplasia increased with the advance of the dysplastic grade. Those of EGF reaction decreased with the advance of the dysplastic grade. It is suggested that morphometry and immunohistochemistry are useful in confirmation of the histological severity of oral epithelial dysplasia.
K Sano
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shika Kiso Igakkai zasshi = Japanese journal of oral biology     Volume:  31     ISSN:  0385-0137     ISO Abbreviation:  Shika Kiso Igakkai Zasshi     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1991-11-22     Completed Date:  1991-11-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7506047     Medline TA:  Shika Kiso Igakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  436-52     Citation Subset:  D    
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MeSH Terms
Antigens, Neoplasm / analysis*
Carcinoembryonic Antigen / blood
Carcinoma, Squamous Cell / pathology*
Chi-Square Distribution
Epidermal Growth Factor / analysis
Leukoplakia, Oral / pathology*
Membrane Glycoproteins / analysis
Mitotic Index
Mouth Neoplasms / pathology*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Membrane Glycoproteins; 0/Mucin-1; 62229-50-9/Epidermal Growth Factor

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