| Morphometric and immunohistochemical investigation of oral epithelial dysplasia and squamous cell carcinoma. | |
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MedLine Citation:
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PMID: 2519286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphometric assessment including epithelial indices which express morphological features of the epithelium, mitotic index, mean nuclear area, mean form factor of the nucleus and cellular infiltration in the stroma was performed in 14 cases with oral non-dysplastic epithelium and 66 cases with dysplastic epithelium. The results from morphometry showed a close relationship to the histological severity of dysplasia determined by the histological criteria of Bánóczy. Immunohistochemical localization of carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and epidermal growth factor (EGF) were investigated in 14 cases of non-dysplastic epithelium, 66 cases of dysplastic epithelium and 16 cases of squamous cell carcinoma, and compared with the morphometric results. Positive rates of CEA and EMA reaction in epithelial dysplasia increased with the advance of the dysplastic grade. Those of EGF reaction decreased with the advance of the dysplastic grade. It is suggested that morphometry and immunohistochemistry are useful in confirmation of the histological severity of oral epithelial dysplasia. |
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Authors:
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K Sano |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Shika Kiso Igakkai zasshi = Japanese journal of oral biology Volume: 31 ISSN: 0385-0137 ISO Abbreviation: Shika Kiso Igakkai Zasshi Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1991-11-22 Completed Date: 1991-11-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7506047 Medline TA: Shika Kiso Igakkai Zasshi Country: JAPAN |
Other Details:
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Languages: eng Pagination: 436-52 Citation Subset: D |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Neoplasm
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analysis* Carcinoembryonic Antigen / blood Carcinoma, Squamous Cell / pathology* Chi-Square Distribution Epidermal Growth Factor / analysis Humans Immunohistochemistry Leukoplakia, Oral / pathology* Membrane Glycoproteins / analysis Mitotic Index Mouth Neoplasms / pathology* Mucin-1 |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Membrane Glycoproteins; 0/Mucin-1; 62229-50-9/Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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