Document Detail

Morphometric and histological study of coronary plaques in stable angina and acute myocardial infarctions.
MedLine Citation:
PMID:  11721469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the morphological difference of coronary plaques in acute myocardial infarction and stable angina to clarify the occurrence basis of these two different myocardial events. METHODS: Sixty-eight acute myocardial infarction cases and 34 stable angina postmortem cases were studied. The coronary arteries were dissected en block, fixed, decalcified, sectioned at a 3 mm interval and processed routinely for histologic examination. A computor-aided planimeter was used to measure plaque and lipid core area. RESULTS: Among the total 4089 coronary blocks in acute myocardial infarction, 2087 (51.0%) had a lipid core over 40% of the plaque area; while among the total 2030 blocks in stable angina, only 209 (10.3%) had a lipid core over 40% of the plaque area (P < 0.05). Sixty-one of the 68 (89.7%) acute myocardial infarction cases had thrombi among which 56 occurred on ruptured plaques; while no thrombus was found in stable angina. In addition, atheroemboli were found in most of the thrombus-negative acute myocardial infarction cases (6/7) but none in SA cases. CONCLUSIONS: Acute myocardial infarction and stable angina had different morphologic basis of the coronary plaques. The former had more plaques with a large lipid core than the latter. Acute myocardial infarction was caused mainly by plaque rupture and associated thrombus. But atheroembolus could be another very important cause of acute myocardial infarction.
H Shi; L Wei; T Yang; S Wang; X Li; L You
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  112     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2001-11-27     Completed Date:  2002-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1040-3     Citation Subset:  IM    
Department of Pathology, Chinese PLA General Hospital, 28 Fu-Xing Road, Beijing 100853, China.
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MeSH Terms
Angina Pectoris / pathology*
Coronary Artery Disease / pathology
Coronary Vessels / pathology*
Middle Aged
Myocardial Infarction / pathology*

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