Document Detail


Morphometric and histological study of coronary plaques in stable angina and acute myocardial infarctions.
MedLine Citation:
PMID:  11721469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare the morphological difference of coronary plaques in acute myocardial infarction and stable angina to clarify the occurrence basis of these two different myocardial events. METHODS: Sixty-eight acute myocardial infarction cases and 34 stable angina postmortem cases were studied. The coronary arteries were dissected en block, fixed, decalcified, sectioned at a 3 mm interval and processed routinely for histologic examination. A computor-aided planimeter was used to measure plaque and lipid core area. RESULTS: Among the total 4089 coronary blocks in acute myocardial infarction, 2087 (51.0%) had a lipid core over 40% of the plaque area; while among the total 2030 blocks in stable angina, only 209 (10.3%) had a lipid core over 40% of the plaque area (P < 0.05). Sixty-one of the 68 (89.7%) acute myocardial infarction cases had thrombi among which 56 occurred on ruptured plaques; while no thrombus was found in stable angina. In addition, atheroemboli were found in most of the thrombus-negative acute myocardial infarction cases (6/7) but none in SA cases. CONCLUSIONS: Acute myocardial infarction and stable angina had different morphologic basis of the coronary plaques. The former had more plaques with a large lipid core than the latter. Acute myocardial infarction was caused mainly by plaque rupture and associated thrombus. But atheroembolus could be another very important cause of acute myocardial infarction.
Authors:
H Shi; L Wei; T Yang; S Wang; X Li; L You
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  112     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2001-11-27     Completed Date:  2002-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1040-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, Chinese PLA General Hospital, 28 Fu-Xing Road, Beijing 100853, China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / pathology*
Coronary Artery Disease / pathology
Coronary Vessels / pathology*
Female
Humans
Male
Middle Aged
Myocardial Infarction / pathology*

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