| Morphometric evidence for a striking B-cell reduction at the clinical onset of type 1 diabetes. | |
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MedLine Citation:
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PMID: 6429944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution and volume of the pancreatic endocrine cells were studied in a case of type 1 diabetes with a duration of approximately 7 days. Immunocytochemical techniques combined with morphometry were used. The PP-cell rich lobe, making up about 10% of the total pancreatic volume, was not included in this study. The volume density and the absolute volume of the B-cells was found to be reduced to about one third to one seventh of the values determined in four controls of similar age and/or pancreatic volume. The A-cell volume was also diminished whereas the D- and PP-cell volume remained constant. As B-cell necroses could not be detected and insulitis was in the initial stages of development it is concluded that the destruction of B-cells proceeds slowly in type 1 diabetes. In the majority of cases it probably starts years before the clinical onset of the disease. |
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Authors:
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G Klöppel; C R Drenck; M Oberholzer; P U Heitz |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Virchows Archiv. A, Pathological anatomy and histopathology Volume: 403 ISSN: 0174-7398 ISO Abbreviation: Virchows Arch A Pathol Anat Histopathol Publication Date: 1984 |
Date Detail:
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Created Date: 1984-08-20 Completed Date: 1984-08-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302198 Medline TA: Virchows Arch A Pathol Anat Histopathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 441-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Count Child Diabetes Mellitus, Type 1 / pathology* Female Histocytochemistry Humans Immunoenzyme Techniques Islets of Langerhans / pathology* |
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