Document Detail


Morphometric characteristics of central retinal artery and vein endothelium in the normal human optic nerve head.
MedLine Citation:
PMID:  21071729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study documents the morphometric features of arterial and venous endothelia in the different laminar regions of the normal human optic nerve head and speculates on the hemodynamic characteristics of the central retinal artery (CRA) and central retinal vein (CRV).
METHODS: Twenty normal human eyes were used. Microcannulation techniques were used to label the cytoskeleton and nuclei of endothelial cells in the CRA and CRV, after which images were captured using confocal microscopy. Length, width, length-to-width ratio, and area measurements were obtained from endothelium and its nuclei. Nucleus position with respect to cell apex and direction of blood flow was also quantified. Comparisons were made between prelaminar, anterior lamina cribrosa, posterior lamina cribrosa, and retrolaminar regions. Venous and arterial endothelial cell morphology was also compared.
RESULTS: There was significant variation in venous endothelial morphology across the different laminar regions; however, no differences were found in arterial endothelial characteristics (all P > 0.1065). Significant differences were found between arterial and venous endothelium in all laminar regions apart from the posterior lamina cribrosa, where only nuclear area (P = 0.0001) and nucleus position (P = 0.0088) were found to be different.
CONCLUSIONS: Arterial-like appearance of venous endothelium in the posterior lamina cribrosa, where pressure gradient forces are predicted to be greatest and CRV luminal diameter is known to be narrowest, implicates this as a site of altered hemodynamic stress. Heterogeneity of venous endothelium may have relevance for understanding ocular vascular diseases such as central retinal vein occlusion.
Authors:
Min H Kang; Chandrakumar Balaratnasingam; Paula K Yu; William H Morgan; Ian L McAllister; Stephen J Cringle; Dao-Yi Yu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-14
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-05-20     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1359-67     Citation Subset:  IM    
Affiliation:
Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cell Nucleus
Cell Size
Endothelium, Vascular / cytology*
Female
Hemodynamics / physiology
Humans
Male
Microscopy, Confocal
Microscopy, Fluorescence
Middle Aged
Optic Disk / blood supply*
Retinal Artery / cytology*
Retinal Vein / cytology*
Young Adult
Comments/Corrections
Comment In:
Invest Ophthalmol Vis Sci. 2012 Mar;53(3):1637; author reply 1637-8   [PMID:  22441495 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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