Document Detail

Morphometric changes in the human pulmonary acinus during inflation.
MedLine Citation:
PMID:  22096115     Owner:  NLM     Status:  MEDLINE    
Despite decades of research into the mechanisms of lung inflation and deflation, there is little consensus about whether lung inflation occurs due to the recruitment of new alveoli or by changes in the size and/or shape of alveoli and alveolar ducts. In this study we use in vivo (3)He lung morphometry via MRI to measure the average alveolar depth and alveolar duct radius at three levels of inspiration in five healthy human subjects and calculate the average alveolar volume, surface area, and the total number of alveoli at each level of inflation. Our results indicate that during a 143 ± 18% increase in lung gas volume, the average alveolar depth decreases 21 ±5%, the average alveolar duct radius increases 7 ± 3%, and the total number of alveoli increases by 96 ± 9% (results are means ± SD between subjects; P < 0.001, P < 0.01, and P < 0.00001, respectively, via paired t-tests). Thus our results indicate that in healthy human subjects the lung inflates primarily by alveolar recruitment and, to a lesser extent, by anisotropic expansion of alveolar ducts.
A J Hajari; D A Yablonskiy; A L Sukstanskii; J D Quirk; M S Conradi; J C Woods
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  112     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-09-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-43     Citation Subset:  IM    
Department of Physics, Washington University, St. Louis, Missouri 63110, USA.
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MeSH Terms
Inhalation / physiology*
Lung Volume Measurements / methods
Magnetic Resonance Imaging / methods
Models, Biological
Pulmonary Alveoli / cytology*
Signal-To-Noise Ratio
Tidal Volume / physiology*
Young Adult
Grant Support
Comment In:
J Appl Physiol (1985). 2012 Mar;112(6):935-6   [PMID:  22162530 ]

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