Document Detail

Morphometric changes after thermal and methacholine bronchoprovocations.
MedLine Citation:
PMID:  15542566     Owner:  NLM     Status:  MEDLINE    
To determine whether there are distinctions in the location and pattern of response between different bronchoprovocations, we performed high-resolution computer-assisted tomography in 10 asthmatic subjects before and after isocapnic hyperventilation of frigid air (HV) and methacholine (Meth). The luminal areas of the trachea, main stem, lobar, and segmental bronchi were computed before and after each provocation and blindly compared. Both stimuli reduced the 1-s forced expiratory volume similarly (percent change in 1-s forced expiratory volume HV = 28.1 +/- 5.5%, Meth = 25.8 +/- 5.2%; P = 0.69) but did so in different fashions. Each provocation was associated with the development of both bronchial narrowing and dilation; however, more airways constricted with HV (67.7%) than with Meth (47.0%; P < 0.001). Furthermore, there was little concordance between either the magnitude or direction of change between stimuli in any region of the lung (r = 0.25). In general, the frequency of narrowing increased with branching. Constriction became more prominent in the lobar regions and increased further in the segmental branches, but a wide range of intensity existed. These data demonstrate that provocational stimuli evoke complex morphometric changes within the tracheobronchial tree and that different agonists produce different patterns. Thermal stimuli chiefly influence the segmental level, whereas the response to Meth develops more distally. Even within this distribution, the same airway does not respond in an identical fashion to different stimuli, so there does not appear to be a uniform trigger zone.
Chakradhar Kotaru; Albert Coreno; Mary Skowronski; Gary Muswick; Robert C Gilkeson; E R McFadden
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2004-11-12
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  98     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-10     Completed Date:  2005-06-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1028-36     Citation Subset:  IM    
Division of Pulmonary and Critical Care Medicine, MetroHealth Medical Center, 2500 MetroHealth Dr., Cleveland, OH 44109, USA.
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MeSH Terms
Anatomy, Cross-Sectional / methods
Asthma / physiopathology*,  radiography*
Bronchi / physiopathology*
Bronchial Provocation Tests / methods*
Bronchography / methods*
Methacholine Chloride / diagnostic use*
Middle Aged
Radiographic Image Interpretation, Computer-Assisted / methods
Grant Support
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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