| Morphometric and biomechanical intestinal remodeling induced by fasting in rats. | |
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MedLine Citation:
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PMID: 12018916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of the small intestine is mechanical to a large degree. To understand the function it is necessary to know how the mechanical stresses and strains can be computed. Nutrition plays an important role in the maintenance of normal gut structure and function. The small intestine undergoes functional changes when food is withheld. To explore the morphological and biomechanical remodeling during starvation, intestinal segments from the fed and fasted rat duodenum, jejunum, and ileum were investigated. After seven days of fasting the animals lost 22% of the body weight and the intestinal mass per length decreased by nearly 40% in the duodenum. Fasting decreased the plasma levels of glucose, insulin, triglyceride, and cholesterol whereas the level of free fatty acids increased (P < 0.001). Fasting decreased the outer circumferential length, wall thickness, wall area, inner circumferential length, and luminal area at the three locations (P < 0.001). Histological examination showed that the mucosal and the submucosal thickness decreased during fasting (P < 0.001), whereas the muscle layers were unchanged. The residual strain on the mucosal surface was compressive. The serosal residual strain was tensile and increased with the highest values after four days of fasting in the duodenum and jejunum (P < 0.001). Fasting shifted the stress-strain curves to the right in both circumferential and longitudinal directions at the three locations (P < 0.04). In conclusion pronounced biomechanical and structural remodeling occurred in the small intestine during fasting for up to one week. Since the contractile properties depend on the passive properties (according to the well-known Hill's model), it can be predicted that the smooth muscle contractile function will also change. |
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Authors:
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Yanling Dou; Søren Gregersen; Jingbo Zhao; Fengyuan Zhuang; Hans Gregersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 47 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-20 Completed Date: 2002-06-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1158-68 Citation Subset: AIM; IM |
Affiliation:
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Institute of Experimental Clinical Research, Aarhus University, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomechanics Blood Glucose / analysis Cholesterol / blood Duodenum / anatomy & histology, physiology Fasting / psychology* Ileum / anatomy & histology, physiology Insulin / blood Intestinal Mucosa / physiology Intestine, Small / anatomy & histology*, physiology* Jejunum / anatomy & histology, physiology Muscle Contraction / physiology Muscle, Smooth / physiology Stress, Mechanical Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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