Document Detail

Morphometric analysis of insulin-like growth factor-I localization in lung tissues of patients with idiopathic pulmonary fibrosis.
MedLine Citation:
PMID:  9817718     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF) through its ability to stimulate fibroblast proliferation and collagen synthesis. However, although alveolar macrophages (AM) have been shown to express this growth factor, it is likely to also have other cellular sources. We sought to determine the distribution of cells expressing IGF-I in lung tissues obtained from 10 patients with IPF and 10 control subjects. We evaluated the levels of IGF-I and of a macrophage/monocyte-specific marker, CD68, by immunocytochemistry and quantified by morphometry. In control subjects, IGF-I was localized principally to AM. In contrast, in IPF patients IGF-I was localized to AM, interstitial macrophages, alveolar epithelial cells, and ciliated columnar epithelial cells. The normalized volume density (Vv) of IGF-I-positive (IGF-I+) interstitial macrophages (Vv of IGF-I+ interstitial macrophages/Vv of lung x 100) was increased in patients with IPF as compared with control subjects, and the ratio of Vv of IGF-I+ to CD68(+) interstitial macrophages correlated with: (1) the degree of clinical impairment in patients with IPF as measured by their clinical-radiologic-physiologic (CRP) score; and (2) the degree of collagen deposition in the interstitium. These findings support a role for interstitial macrophages as a source of IGF-I in IPF.
S T Uh; Y Inoue; T E King; E D Chan; L S Newman; D W Riches
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  158     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1626-35     Citation Subset:  AIM; IM    
Departments of Pediatrics and Medicine, National Jewish Medical, Denver, CO 80206, USA.
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MeSH Terms
Antigens, CD / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Cell Division
Cilia / pathology
Collagen / biosynthesis
Epithelial Cells / pathology
Fibroblasts / pathology
Insulin-Like Growth Factor I / analysis*,  physiology
Lung / pathology*
Macrophages, Alveolar / pathology
Middle Aged
Monocytes / pathology
Pulmonary Alveoli / pathology
Pulmonary Fibrosis / pathology*
Grant Support
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 67763-96-6/Insulin-Like Growth Factor I; 9007-34-5/Collagen

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