Document Detail


Morphometric analysis of hypothalamic cells showing c-Fos proteins after movement restriction and EHF-irradiation.
MedLine Citation:
PMID:  18313906     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A morphometric analysis of hypothalamic cells containing c-Fos-like protein detected by an indirect immunoperoxidase method was carried out to clarify the responses to movement restriction and skin electromagnetic high frequency (EHF) irradiation (7.1mm, 42.2GHz, 20mW output power) simultaneously to three acupuncture projection areas. The morphometry of c-Fos-protein positive neurons by their number and type was analyzed. Movement restriction (40min) induced c-Fos protein expression primarily in cells with 10-50mum(2) sizes (associative type neurons) only in anterior hypothalamic nucleus and lateral hypothalamic area; while additional EHF-irradiation of acupuncture projection areas (under movement restriction) induced c-Fos expression in all hypothalamic structures and mostly in cells with 70-150mum(2) sizes (relay type neurons), i.e. changed the pattern of activated cell type distribution. In conclusion, the findings show that modest stress under which experimental animals often are exposed increase c-Fos protein expression in hypothalamic centers and skin EHF-irradiation of acupuncture projection areas seem to increase that.
Authors:
N S Novikova; S V Perekrest; V J Rogers; E A Korneva
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Publication Detail:
Type:  Journal Article     Date:  2008-03-03
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  15     ISSN:  0928-4680     ISO Abbreviation:  Pathophysiology     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  -    
Affiliation:
Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, RAMS, Pavlov St. 12, Saint-Petersburg 197376, Russia.
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