Document Detail


Morphometric differences in the Heschl's gyrus of hearing impaired and normal hearing infants.
MedLine Citation:
PMID:  20841321     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigates the morphometry of Heschl's gyrus and its included primary auditory cortex (PAC) in hearing impaired (HI) and normal hearing (NH) infants. Fourty-two infants, age 8-19 months, with NH (n = 26) or hearing impairment (n = 16) were studied using high-resolution 3D magnetic resonance imaging. Gray matter (GM) and white matter (WM) volumes were obtained using software for automatic brain imaging segmentation to estimate the volume of each tissue within manually defined regions for the anterior portion of Heschl's gyrus (aHG) in each individual subject, transformed to an infant brain template space. Interactions among group (HI, NH), tissue type (GM, WM), and hemisphere (left, right) were examined using analysis of variance. Whole-brain voxel-based morphometry was utilized to explore volume differences between groups across the entire brain. The HI group showed increased GM and decreased WM in aHG compared with the NH group; likely effects of auditory deprivation. The HI group did not exhibit their typical L > R asymmetry pattern that the NH group showed. Increased GM in aHG in HI infants may represent abnormal cortical development in PAC as seen in animal models of sensory deprivation. Lower WM volume is consistent with studies with deaf adults.
Authors:
Kristen M Smith; Marc D Mecoli; Mekibib Altaye; Marcia Komlos; Raka Maitra; Ken P Eaton; John C Egelhoff; Scott K Holland
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-13
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  21     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  2012-03-16     Revised Date:  2012-09-24    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  991-8     Citation Subset:  IM    
Affiliation:
Pediatric Neuroimaging Research Consortium, Cincinnati Children's Research Foundation, Cincinnati, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Atrophy
Auditory Cortex / anatomy & histology,  growth & development*,  pathology*
Brain Mapping / methods
Deafness / pathology*,  physiopathology
Female
Functional Laterality / physiology
Humans
Image Processing, Computer-Assisted / methods
Imaging, Three-Dimensional / methods
Infant
Magnetic Resonance Imaging / methods
Male
Reference Values
Sensory Deprivation / physiology*
Grant Support
ID/Acronym/Agency:
R01-DC07186/DC/NIDCD NIH HHS
Comments/Corrections

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