Document Detail

Morphometric correlation of impulsivity in medial prefrontal cortex.
MedLine Citation:
PMID:  23274773     Owner:  NLM     Status:  MEDLINE    
Impulsivity is a complex behaviour composed of different domains encompassing behavioural dis-inhibition, risky decision-making and delay discounting abnormalities. To investigate regional brain correlates between levels of individual impulsivity and grey matter volume, we performed voxel-based morphometric correlation analysis in 34 young, healthy subjects using impulsivity scores measured with Barratt Impulsivity Scale-11 and computerized Kirby's delay discounting task. The VBM analysis showed that impulsivity appears to be reliant on a network of cortical (medial prefrontal cortex and dorsolateral prefrontal cortex) and subcortical (ventral striatum) structures emphasizing the importance of brain networks associated with reward related decision-making in daily life as morphological biomarkers for impulsivity in a normal healthy population. While our results in healthy volunteers may not directly extend to pathological conditions, they provide an insight into the mechanisms of impulsive behaviour in patients with abnormalities in prefrontal/frontal-striatal connections, such as in drug abuse, pathological gambling, ADHD and Parkinson's disease.
Sang Soo Cho; Giovanna Pellecchia; Kelly Aminian; Nicola Ray; Barbara Segura; Ignacio Obeso; Antonio P Strafella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-30
Journal Detail:
Title:  Brain topography     Volume:  26     ISSN:  1573-6792     ISO Abbreviation:  Brain Topogr     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2014-01-23     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  8903034     Medline TA:  Brain Topogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-87     Citation Subset:  IM    
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MeSH Terms
Attention / physiology
Brain Mapping*
Decision Making
Impulsive Behavior / pathology*
Magnetic Resonance Imaging
Neuropsychological Tests
Prefrontal Cortex / pathology*
Psychiatric Status Rating Scales
Statistics as Topic
Young Adult
Grant Support
110962-1//Canadian Institutes of Health Research; MOP-110962//Canadian Institutes of Health Research

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