| Morphology studies of the human fetal cochlea in turner syndrome. | |
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MedLine Citation:
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PMID: 19050645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Turner syndrome (TS) is the most frequent sex chromosome abnormality, and sensorineural hearing loss is common. We aimed to determine whether there are consistent morphologic cochlear abnormalities during gestational development that could be associated with TS. DESIGN: The histology of nine fetal temporal bones of TS autopsied after spontaneous abortion was studied. RESULTS: Gross morphologic examination of the TS cochleae failed to reveal a pattern of structural abnormalities that would explain the development of sensorineural hearing loss. Mondini-like cochlear dysplasia was observed in one 13-wk-old TS fetus. CONCLUSION: We could not demonstrate a consistent pattern of cochlear malformations. |
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Authors:
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John H Fish; Ilona Schwentner; Joachim Schmutzhard; Irene Abraham; Andrea Ciorba; Alessandro Martini; Consolato Sergi; Anneliese Schrott-Fischer; Rudolf Glueckert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ear and hearing Volume: 30 ISSN: 1538-4667 ISO Abbreviation: Ear Hear Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-06 Completed Date: 2009-04-21 Revised Date: 2010-03-23 |
Medline Journal Info:
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Nlm Unique ID: 8005585 Medline TA: Ear Hear Country: United States |
Other Details:
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Languages: eng Pagination: 143-6 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, Research Laboratories for Inner Ear Biology, University Hospital, Medical University Innsbruck, Innsbruck, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cochlea
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embryology* Fetus / abnormalities, pathology* Gestational Age Hearing Loss, Sensorineural / etiology* Humans Temporal Bone / embryology Turner Syndrome / complications, embryology*, pathology* |
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