Document Detail


Morphology of skin microvasculature in psoriasis.
MedLine Citation:
PMID:  2644867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To establish the character of microvascular changes in psoriatic skin and their specificity, 29 skin biopsies of psoriatics (20 in exacerbation and 9 in a stationary stage) were investigated using histologic, histochemical, immunomorphologic, electron-microscopic, and morphometric methods. Five biopsies of uninvolved skin in scleroderma and five of diabetes mellitus patients were studied with the same technique for comparison. The results showed that structural changes depend on disease stage and the clinical appearance of lesions. Microvascular changes precede papule appearance during exacerbation and gradually increase during papule development. They comprise vascular dilatation, bridged fenestrations and gaps in endothelium, edematous areas in the cytoplasm of endotheliocytes, myocytes and pericytes, basement-membrane-zone thickening, and cell extravasation--signs of increased vascular permeability. Immunoglobulin G deposits in vascular walls, degranulation of mast cells, and extravasation of lymphocytes and neutrophils indicate that inflammation is a basic process during exacerbation and that immune mechanisms play an important role in the pathogenesis of inflammation. Microvascular changes in scleroderma and diabetes mellitus are different in nature and do not resemble those in psoriasis.
Authors:
V N Mordovtsev; V I Albanova
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  11     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-16     Completed Date:  1989-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-42     Citation Subset:  IM    
Affiliation:
Central Research Institute of Dermatology and Venereology, Moscow, USSR.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arterioles / pathology
Basement Membrane / pathology
Capillaries / pathology
Diabetes Mellitus / pathology
Female
Fluorescent Antibody Technique
Humans
Immunoglobulin G
Male
Microscopy, Electron
Psoriasis / pathology*
Scleroderma, Systemic / pathology
Skin / blood supply*
Venules / pathology
Chemical
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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