Document Detail

Morphology of skin microvasculature in psoriasis.
MedLine Citation:
PMID:  2644867     Owner:  NLM     Status:  MEDLINE    
To establish the character of microvascular changes in psoriatic skin and their specificity, 29 skin biopsies of psoriatics (20 in exacerbation and 9 in a stationary stage) were investigated using histologic, histochemical, immunomorphologic, electron-microscopic, and morphometric methods. Five biopsies of uninvolved skin in scleroderma and five of diabetes mellitus patients were studied with the same technique for comparison. The results showed that structural changes depend on disease stage and the clinical appearance of lesions. Microvascular changes precede papule appearance during exacerbation and gradually increase during papule development. They comprise vascular dilatation, bridged fenestrations and gaps in endothelium, edematous areas in the cytoplasm of endotheliocytes, myocytes and pericytes, basement-membrane-zone thickening, and cell extravasation--signs of increased vascular permeability. Immunoglobulin G deposits in vascular walls, degranulation of mast cells, and extravasation of lymphocytes and neutrophils indicate that inflammation is a basic process during exacerbation and that immune mechanisms play an important role in the pathogenesis of inflammation. Microvascular changes in scleroderma and diabetes mellitus are different in nature and do not resemble those in psoriasis.
V N Mordovtsev; V I Albanova
Related Documents :
17305637 - Altered cd40 and e-cadherin expression--putative role in oral lichen planus.
15989537 - Emerging drugs in psoriasis.
15192327 - Potentiation of uvb-induced apoptosis by novel phytosphingosine derivative, tetraacetyl...
15466397 - Hyaluronan participates in the epidermal response to disruption of the permeability bar...
19628407 - Epithelial cells as immune effector cells: the role of cd40.
23946597 - Tumor necrosis factor-α mediates jnk activation response to intestinal ischemia-reperfu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  11     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-16     Completed Date:  1989-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-42     Citation Subset:  IM    
Central Research Institute of Dermatology and Venereology, Moscow, USSR.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arterioles / pathology
Basement Membrane / pathology
Capillaries / pathology
Diabetes Mellitus / pathology
Fluorescent Antibody Technique
Immunoglobulin G
Microscopy, Electron
Psoriasis / pathology*
Scleroderma, Systemic / pathology
Skin / blood supply*
Venules / pathology
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Combination of the APAAP and the IGSS techniques for double-labeling with two different monoclonal a...
Next Document:  Low-grade primary cutaneous adenosquamous (mucoepidermoid) carcinoma. Report of a case and review of...