Document Detail


Morphology of the seminal vesicle of Calomys callosus submitted to experimental chronic alcoholism.
MedLine Citation:
PMID:  11989779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the present study was to assess the possible toxic effects of chronic alcohol ingestion on the ultrastructure of the lining epithelium of the seminal vesicle of the rodent Calomys callosus, in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the male reproductive apparatus. Twenty six adult animals aged three months were divided into two experimental groups. The control group received a solid diet (Purina chow) and tap water, and the alcoholic group received the same solid diet and ethanol P.A. diluted 20% in water (v/v). After 210 days of treatment, all animals were anaesthetised, weighed and sacrificed. At the end of treatment, mean body and seminal vesicle weight did not differ between control and alcoholic animals. The epithelial cells of the alcoholic group showed many alterations such as the presence of lipid droplets of different sizes, nuclei with increased peripheral chromatin and greater electrondensity, megamitochondria, and intense dilatation of the cisterns of the granular endoplasmic reticulum. It was concluded that 20% ethanol provokes marked ultrastructural lesions in the seminal vesicle.
Authors:
M Martinez; E C Mattos; W J Mello; V H Cagnon; F E Martinez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of submicroscopic cytology and pathology     Volume:  33     ISSN:  1122-9497     ISO Abbreviation:  J. Submicrosc. Cytol. Pathol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804312     Medline TA:  J Submicrosc Cytol Pathol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  453-61     Citation Subset:  IM    
Affiliation:
Department of Morphology and Pathology, Federal University of São Carlos, SP, Brazil. martinez@power.ufscar.br
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / pathology*
Animals
Epithelium / ultrastructure
Male
Mice
Seminal Vesicles / ultrastructure*
Testosterone / blood
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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