Document Detail

Morphology of the placenta in fetal I-cell disease.
MedLine Citation:
PMID:  837559     Owner:  NLM     Status:  MEDLINE    
Placentas were studied from three interrupted pregnancies of a mother whose first liveborn child had I-cell disease (mucolipidosis II). I-cell disease of the fetus was shown by investigation of the amniotic fluid, fetal cells and the aborted fetus in two pregnancies, but in the third case placenta was the only available product of conception. In every placenta extensive vacuolization of the syncytiotrophoblastic layer of the chorionic villi and chorionic mesenchymal cells was found. In electron microscopy the inclusions were identical to those of other tissues in I-cell disease. The importance of histological study of placenta in unexplained spontaneous abortions needs to be emphasized, since this may be the only way of detecing new cases of lysosomal storage diseases.
J Rapola; P Aula
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical genetics     Volume:  11     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-28     Completed Date:  1977-04-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
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MeSH Terms
Abortion, Habitual
Abortion, Induced
Amniotic Fluid / cytology
Chorionic Villi / ultrastructure
Fetal Diseases / diagnosis*
Microscopy, Electron
Mucolipidoses / diagnosis*
Placenta / ultrastructure*
Prenatal Diagnosis
Vacuoles / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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