| Morphology and peroxidase cytochemistry of mouse promonocytes, monocytes, and macrophages. | |
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MedLine Citation:
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PMID: 5508378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mouse promonocytes have been identified and studied in cultures of bone marrow cells. These cells have a diameter of 14-20 micro, and in stained preparations reveal a large, indented or folded nucleus, and basophilic, finely granular cytoplasm. The living promonocyte viewed by phase contrast shows additional features: nucleoli, small dense bodies, and vesicles in the cytoplasm adjacent to the nuclear hilus, and slight membrane ruffling. Prominent ultrastructural components of promonocytes include a well developed Golgi apparatus, small numbers of centrosomal granules and vacuoles, extensive ribosomal aggregates, and finger-like projections of the cell surface. Promonocytes engage in pinocytosis and phagocytosis, but they are less active in these functions than are peripheral blood monocytes of peritoneal macrophages. Promonocytes are positive for peroxidase, the reaction product being localized to granules most of which are centrally situated in the cell. Monocytes in blood or in inflammatory peritoneal exudates display much smaller numbers of peroxidase-positive granules, and various types of mature mouse macrophages are peroxidase negative. |
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Authors:
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R van Furth; J G Hirsch; M E Fedorko |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 132 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1970 Oct |
Date Detail:
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Created Date: 1971-05-25 Completed Date: 1971-05-25 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 794-812 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow / enzymology* Bone Marrow Cells* Culture Techniques Femur Histocytochemistry Macrophages / cytology*, enzymology* Mice Microscopy, Electron Monocytes / cytology*, enzymology* Peritoneum / cytology Peroxidases / analysis* Phagocytosis Pinocytosis |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.-/Peroxidases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1970 by The Rockefeller University Press Received Day: 27 Month: 4 Year: 1970 Print publication date: Day: 1 Month: 10 Year: 1970 Volume: 132 Issue: 4 First Page: 794 Last Page: 812 ID: 2138863 PubMed Id: 5508378 |
| MORPHOLOGY AND PEROXIDASE CYTOCHEMISTRY OF MOUSE PROMONOCYTES, MONOCYTES, AND MACROPHAGES | |
| Ralph van Furth | |
| James G. Hirsch | |
| Martha E. Fedorko | |
| From the Department of Microbial Diseases, University Hospital, Leiden, The Netherlands and The Rockefeller University, New York 10021 |
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