Document Detail


Morphology of dynamic graciloplasty compared with the anal sphincter.
MedLine Citation:
PMID:  8500373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dynamic graciloplasty for fecal incontinence includes gracilis muscle transposition around the anal canal as a new sphincter and subsequent electrical stimulation. The aim of electrical stimulation is to transform the gracilis fast-twitch, "fatigue-prone" fibers into slow-twitch, "fatigue-resistant" fibers to achieve a sustained tonic contraction. The latter is considered essential for sphincter function. Therefore, the following features of transposed gracilis muscle morphology were studied in nine patients before and after electrical stimulation: 1) the percentage of Type I fibers, 2) the lesser diameter of these fibers, and 3) the positive collagen staining area. Furthermore, the external and sphincter and gracilis muscle histology was investigated in six autopsy cases. The mean percentage of Type I, slow-twitch, fatigue-resistant fibers in transposed gracilis muscle increased from 46 percent before electrical stimulation to 64 percent (P < 0.01, paired Student's t-test) after electrical stimulation. The mean lesser diameter of these fibers did not change significantly (from 32 to 29 microns), and the mean percentage of collagen increased from 4 percent before electrical stimulation to 7 percent (P < 0.01) afterward. The external sphincter in cadavers demonstrated a predominance of Type I fibers (80 percent) with a lesser diameter of 23 microns and a high percentage (12 percent) of collagen. Gracilis muscle histology was uniform at six different sample sites in these cadaver dissections. We conclude that electrical stimulation induces histologic changes in transposed gracilis muscle, allowing this muscle to function as an external anal sphincter.
Authors:
J Konsten; C G Baeten; M G Havenith; P B Soeters
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  36     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-06-29     Completed Date:  1993-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  559-63     Citation Subset:  IM    
Affiliation:
Department of Surgery, Maastricht University Hospital, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Anal Canal / anatomy & histology*,  chemistry,  physiology
Collagen / analysis
Electric Stimulation
Fecal Incontinence / surgery
Humans
Muscle Contraction
Muscles / anatomy & histology*,  chemistry,  physiology
Thigh
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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