| Morphological variants of leukemic cells in B chronic lymphocytic leukemia are associated with different T cell and NK cell abnormalities. | |
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MedLine Citation:
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PMID: 9257876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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B chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease. The different morphological variants of leukemic B cells appear to define different clinical groups of patients. Several abnormalities have been found in T lymphocytes and natural killer (NK) cells from B-CLL patients. We have investigated the phenotypic and functional characteristics of purified CD2+ cells from B-CLL patients at Binet's stage A and classified according to the neoplastic B lymphocyte morphology criteria: 32 patients with typical B-CLL and 12 patients with atypical B-CLL. Forty-three age and sex matched healthy controls were also studied. In fresh purified CD2+ cells from typical B-CLL patients, percentages of CD4+, CD4+CD45RA+, CD8+CD45RA+ T lymphocytes and CD3-CD56+ (NK) cells were significantly higher than those found in atypical B-CLL patients. However, in DC2+ cells from typical B-CLL patients, percentages of CD3+, CD3+DR+, CD8+, CD4+CD45RO+, and CD3+CD56+ cells were significantly lower than those found in atypical B-CLL patients. Increased percentage of NK cells was only found in typical B-CLL patients. The proliferative response and the production of interleukin (IL)-2 and IL-4 by phytohemagglutinin (PHA) stimulated CD2+ cells were significantly higher in typical B-CLL patients than in atypical B-CLL patients. We concluded that different patterns of phenotypic and functional alterations in the T lymphocytes and NK cells of B-CLL patients are found in patients with typical or atypical B-CLL defined according to the morphology of the leukemic cells. |
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Authors:
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E Reyes; A Prieto; F Carrion; J Garcia-Suarez; F Esquivel; M Alvarez-Mon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hematology Volume: 55 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 175-82 Citation Subset: IM |
Affiliation:
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Principe de Asturias University Hospital, Department of Medicine, University of Alcala de Henares, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antigens, CD2 / analysis Antigens, CD3 / analysis Antigens, CD4 / analysis Antigens, CD45 / analysis Antigens, CD56 / analysis Antigens, CD8 / analysis B-Lymphocytes / pathology* Female Humans Interleukin-2 / biosynthesis Interleukin-4 / biosynthesis Killer Cells, Natural / immunology* Leukemia, Lymphocytic, Chronic, B-Cell / immunology*, pathology* Lymphocyte Count Male Middle Aged T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD2; 0/Antigens, CD3; 0/Antigens, CD4; 0/Antigens, CD56; 0/Antigens, CD8; 0/Interleukin-2; 207137-56-2/Interleukin-4; EC 3.1.3.48/Antigens, CD45 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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