Document Detail


Morphological and quantitative aspects of the development of cytoplasmic granules in concanavalin A-stimulated normal human lymphocytes.
MedLine Citation:
PMID:  1693648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied normal human lymphocytes stimulated by concanavalin A to determine the rate and extent of development of cytoplasmic granules. Morphological studies on stimulated lymphocytes were undertaken at the light and electron microscopic level. The percentage of T lymphocytes bearing different CD antigens (CD3, CD4, and CD8) that also contained cytoplasmic granules was also assessed. Granules were identified in a high percentage of lymphocytes bearing each of the three CD markers studied.
Authors:
A McGirl; G Shea; M Melinn; H McLaughlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  47     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-13     Completed Date:  1990-07-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  514-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, University College Dublin, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Cell Survival / drug effects,  physiology
Concanavalin A / pharmacology*
Cytoplasmic Granules / physiology,  ultrastructure*
Humans
Lymphocyte Activation / physiology*
Microscopy, Electron / methods
Staining and Labeling
T-Lymphocytes / drug effects*,  physiology,  ultrastructure
Chemical
Reg. No./Substance:
11028-71-0/Concanavalin A

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