Document Detail

Morphological precursors of hepatocellular carcinoma: a morphometrical analysis.
MedLine Citation:
PMID:  3038718     Owner:  NLM     Status:  MEDLINE    
Morphometrical analysis of different types of liver cells was performed in cases of chronic active hepatitis (CAH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). The area and a form factor (form AR) of nuclei and cytoplasms were determined, and the nucleo-cytoplasmic ratio (N/C) was calculated in normal hepatocytes, HBsAg-positive cells, large dysplastic cells, cancer cells and in a liver cell population identifiable as "small dysplastic cells" (small cells). The nucleo-cytoplasmic ratio of the small cells and of the neoplastic cells was roughly the same and the highest. Large dysplastic cells showed a small nucleo-cytoplasmic ratio, almost comparable with that of normal hepatocytes and similar to that of HBsAg-positive cells. Since cellular precursors of liver cancer are expected to have a nucleo-cytoplasmic ratio similar to that of neoplastic cells, our morphometrical evaluation indicates small cells as the true precancerous cells; liver cell dysplasia (large dysplastic cells), as described by Anthony et al., should not be considered as a true preneoplastic change.
A Giannini; G Zampi; F Bartoloni; S Omer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  34     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-28     Completed Date:  1987-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  95-7     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Hepatocellular / pathology*
Cell Nucleus / ultrastructure
Cytoplasm / ultrastructure
Hepatitis B / pathology
Hepatitis, Chronic / pathology
Liver Cirrhosis / pathology
Liver Neoplasms / pathology*
Precancerous Conditions / pathology*

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