Document Detail

Morphological observations of megakaryocytic emperipolesis in the bone marrow of rats treated with lipopolysaccharide.
MedLine Citation:
PMID:  8844604     Owner:  NLM     Status:  MEDLINE    
A morphological examination was performed on megakaryocytic emperipolesis containing neutrophils in the rat bone marrow induced by intravenous administration of lipopolysaccharide (LPS). Ultrastructurally, the engulfed neutrophils appeared to lie in the demarcation membrane system (DMS) of megakaryocytes. Intact neutrophils generally migrated from DMS into the lumen of vascular sinus across the endothelium of sinus wall. However, some neutrophils showed characteristics of apoptosis, and DNA fragmentation was detected in these cells by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling method. Thus, the cell death of neutrophils engulfed by megakaryocytes was thought to be apoptosis. The present results suggest that megakaryocytes contribute to random selection of an excess of neutrophils in the bone marrow of rats treated with LPS.
M Tanaka; Y Aze; K Shinomiya; T Fujita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  58     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-23     Completed Date:  1996-12-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  IM    
Fukui Institute for Safety Research, Ono Pharmaceutical Co. Ltd, Japan.
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MeSH Terms
Bone Marrow / drug effects,  pathology*
Erythrocyte Count / drug effects
Hemoglobins / metabolism
Leukocyte Count / drug effects
Lipopolysaccharides / toxicity*
Megakaryocytes / drug effects,  pathology*,  ultrastructure
Neutrophils / drug effects,  pathology*,  ultrastructure
Platelet Count / drug effects
Rats, Sprague-Dawley
Reg. No./Substance:
0/Hemoglobins; 0/Lipopolysaccharides

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