| Morphological and morphometrical alterations of the osteochondral junction in perinatal necropsies. | |
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MedLine Citation:
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PMID: 18995202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infants who die during the perinatal period could present the following upon examination of the ribs: alterations of the osteochondral junction (OCJ) that could be related to intrauterine growth restriction, placental alterations, maternal disorders, and congenital abnormalities. The aim of this study was to identify the morphological alterations of the OCJ in the autopsied infants and the factors associated with its pathogenesis. The OCJ from 254 infants were sequentially autopsied and analyzed. Hematoxylin-eosin and blue Masson's trichrome stains were used for examination. The expression in the chondrocytes of the cartilage oligomeric matrix protein (COMP) was measured using a polyclonal antibody. There were 199 (78.3%) cases with normal OCJ and 55 (22%) cases with alterations; among these, 38 (14.9%) cases have an increased cartilage matrix at the free bone marrow zone of the OCJ (ICM), 10 (3.9%) cases have a bizarre pattern (BZ), 5 (2%) cases have a bone tissue formation closing de growth channels (MCO) of the OCJ, and 2 (0.8%) cases have bone marrow cells encroaching the free bone marrow zone. The length of the proliferative zone was different in the groups with alterations of the OCJ (P < .001), being higher in the group of patients with MCO and ICM (P < .05). In the group with BZ, the length was smaller (P < .05). The analysis of the OCJ is important in the autopsies performed at the perinatal period, and this study contributes for a better understanding of the mechanisms related to the etiology of these alterations. |
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Authors:
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Ana Karina Marques Salge; Tarcísio Barcelos Evangelista; Rogério Carrijo Canno; Pricila Bernardino; Nátila Alves Franco; Renata Pereira Paes Santos; Renata Calciolari Rossi e Silva; Rosana Rosa Miranda Côrrea; Janaína Valadares Guimarães; Luiz César Peres; Eumenia Costa da Cunha Castro |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-07 |
Journal Detail:
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Title: Annals of diagnostic pathology Volume: 12 ISSN: 1532-8198 ISO Abbreviation: Ann Diagn Pathol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2009-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800503 Medline TA: Ann Diagn Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 397-400 Citation Subset: IM |
Affiliation:
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Nursing School, Goiás Federal University, Goiânia, Brazil. anakarina@fen.ufg.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autopsy Bone Marrow / pathology Cartilage / pathology Cell Proliferation Chondrocytes / metabolism, pathology* Extracellular Matrix Proteins / metabolism Female Glycoproteins / metabolism Humans Infant, Newborn Male Osteogenesis* Retrospective Studies Ribs / pathology* Stillbirth* |
| Chemical | |
Reg. No./Substance:
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0/Extracellular Matrix Proteins; 0/Glycoproteins; 0/cartilage matrix protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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