Document Detail

Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone.
MedLine Citation:
PMID:  20012988     Owner:  NLM     Status:  MEDLINE    
Giant cell tumour of bone (GCTB) is a primary tumour of bone that may rarely, in the absence of malignant cytological features, produce metastatic lesions, most commonly in the lungs. Whether these lung nodules represent true neoplastic secondaries or implants derived from the primary tumour is not certain. In this study, we have analysed the morphological and immunophenotypic features of 19 conventional GCTBs and corresponding lung nodules for expression of macrophage, osteoclast, proliferation and tumour-associated markers. A striking morphological feature of all GCTBs that produced lung secondaries was the presence of large areas of haemorrhage and thrombus formation; mononuclear and multinucleated cells of GCTB were frequently found within these areas of haemorrhage and thrombus. A similar pattern of CD14, CD33, HLA-DR and CD51 expression was seen in macrophages and giant cells in primary and secondary tumours. Smooth muscle actin expression was frequently noted in primary GCTBs that recurred and metastasised. No difference was seen in the expression of p53, p63, Ki-67, cyclin D1 or Bcl-2 in primary and secondary tumours. Our findings suggest that most lung nodules associated with primary conventional GCTBs are implants derived from tumour emboli formed in areas of haemorrhage and thrombus formation within the primary tumour.
M Alberghini; K Kliskey; T Krenacs; P Picci; L Kindblom; R Forsyth; N A Athanasou
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Publication Detail:
Type:  Journal Article     Date:  2009-12-15
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  456     ISSN:  1432-2307     ISO Abbreviation:  Virchows Arch.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Istituto Ortopedico Rizzoli, Bologna, Italy.
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MeSH Terms
Antigens, CD / metabolism
Antigens, CD14 / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Bone Neoplasms / immunology,  pathology*
Giant Cell Tumor of Bone / immunology,  pathology*
HLA-DR Antigens / metabolism
Integrin alphaV / metabolism
Lung Neoplasms / immunology,  pathology,  secondary*
Middle Aged
Osteoclasts / pathology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD14; 0/Antigens, Differentiation, Myelomonocytic; 0/CD33 antigen; 0/HLA-DR Antigens; 0/Integrin alphaV

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